Study On Control Of Surficial Topological Structure & Blood Compatibility Of Liquid Crystal/Polymer Composite Membranes

Using the "bionic design" idea, by imitating the liquid crystal structure on the surface of biological membranes, the cholesteryl liquiderystal(LC) was blent with PVC to produced unoriented and oriented polymer/LC composite membranes, which researehed as anti-clotting biomaterial. the surficial topological structure of the LC domain's size,distribution and arrangement which is control by adjusting the liquid content and heat-treated at different inducing temperatures, The effect of the structural characteristics of membrane surface morphology on protein adsorption behavior and blood compatibility are studied.The structure and performance of the product CTGC were observed by Infrared Spectrum, Optical Polarization Microscopy and 1H-NMR.The CTGC was blent with PVC to prepare series composite membranes in SIPS method respectively, the surficial topological structure and performance of various composite membrane,include the phase separation degree, LC domain shape, LC domain distribution, were observed through optical polarization microscopy, scanning electron microscopy and Atomic Force Microscope. And the relationships between LC content and inducing conditions was discussed.The results show that the characteristic surficial shape of composite membranes was effected by LC contents and inducing, liquid crystals exhibit circular shape and distribute uniformly,the characteristic surficial shape of composite membreanes was effected by LC contents and inducing conditions.Contact angle test result indicates that the hydrophilicity of materials icreased With the increase of LC content, the rise of induced temperature and the increase of orientation degree, and the polymer/LC composite membrane's BSA absorption properties under different temperature were determined by Coomassie brilliant blue method. topological structure of composite membranes were under control by adjusting the LC contents and different inducing conditions properly. At the same environmental temperaturee, composite membrane's BSA adsorance influenced by the content of LC..With the increase of LC content, BSA adsorption decreased; but at the same LC content, the higher of inducing temperature, the more of BSA adsorbance. And BSA adsorance is influenced by environmental temperature and Lc content. Compared to unoriented composite membranes, the BSA adsorance of oriented composite membranes has low environmental temperature dependenceBlood compatibility of those composite membranes were measurement by haemolysis ratio, the prothrombin time test and platelet adhesion test The results revealed that the haemolysis ratio of composite membranes with different topological structure and contents are all less than 5%, the platelets attached on composite membrane surface play more natural condition. In short, different with the traditional polymer/LC composite membranes, the composite membranes new type liquid crystal compound improve the anti-clotting properties of the polymer membranes in a greater degree.