The Effect Of Regulator Of Nitric Oxide (NO)/cyclic Guanosine Momophosphate (cGMP) Pathway In Cochlea Of Guinea Pig

Objective To investigate the effect of nitric oxide (NO)/ cyclic guanosine momophosphate(cGMP) pathway for cochlear function. Methods By perfusing whole cochlea, Result In fourth group the threshold of CAP is lower 9 dB SPL than in second group, and there was significant different between both groups (P<0.01) . While there were not significance between fourth group and fifth group. In ninth group the threshold of CAP is lower 7 dB SPL than in eighth group, and there was significant different between both groups(P<0.01) . Conclusion (1) Ca2+-ATPase inhibitor can take effect the function of cochlea by inhibiting Ca2+-ATPase.(2) L-arginine can antagonize in part the function of Ca2+-ATPase inhibitor. (3) The nitric oxide (NO)/ cyclic guanosine momophosphate(cGMP) pathway can regulate cochlear potential. (4) To indirectly prove that supporting cells join to modulate the function of cochlea. (5) Nitric oxide (NO)/ cyclic guanosine momophosphate(cGMP) pathway can regulate cochlear...