The Effect Of Yi Qi Huo Xie Herbs On The Endothelial Cells And Platelets In Chronic Cor Pulmonale

Objective To observe the clinical effect of Yi Qi Huo Xie herbs in treating the patients with chronic cor pulmonale and to explore its partial mechanism by determining the change and relationship of oxidative and antioxidant system, endothelial cells and platelets.Methods 57 patients were devided into two groups: regular therapy group (control group) and convention plus Yi Qi Huo Xie herbs group(treat group).The 27 patients in the control group received regular management such as oxygen therapy, antibiotics, bronchodilator drugs,and so on , the other 30 patients were treated with Yi Qi Huo Xie herbs 150ml 3 times a day besides the regular treatment. The lipid peroxides(LPO), superoxide dismutase (SOD), a -granule membrane protein(GMP140) and circulating endothelial cells(CEC) were measured respectively before and after treatment. The results were compared with those of 13 cases of healthy persons in the same period. All the patients examined the arterial blood gas and analyse the relations among the oxidative and antioxidant system, endothelial cells and platelets functions.Results: 1.In the treatment group, the.markedly effective rate(86.6%) was significant higher than that(64.2%) of the control group('P<0. 05). 2. The levels of LPO,GMP140, CEC in all the patientsbefore therapy were significantly higher than those of the healthy(all P<0.01), and there were marked decreasement of levels of those after treatment (all P<0. 01).On the contrary, the levels of SOD in all the patients before therapy were remarkablely lower than that in the healthy and increased after treatment. 3. The increasement of SOD in the treatment from 443±137μg·g-1Hb-1 to 719±138μg·g-1Hb-1 were significantly obviously than that of the controlled group from 467±149μg·g-1Hb-1 to 584±97μ g·g-1Hb-1 (P<0. 01) . In the treatment group, the decreasement of LPO, GMP140, CEC from 12.3±3.1μmmol/L, 2340±1476 molecule/platelet, 13. 48±2. 61个/0.9μL to 6. 3±1. 7μ mmol/L, 1348 ±310 molecule/platelet, 6.91±1.01个/0.9μL respectively were remarkablely obvious than those in the control group from 11.9± 2.3μmmol/L, 2187±1546 molecule/platelet, 12. 54±2.58个/0.9μ L to 9. 1±1.6μ mmol/L , 1513±337 molecule/platelet, 9.74±0.98个/0.9 μL respectively (all P<0. 01). 4. The PaO2 were improved in both patient groups and there were more significantly improvement in the treated group(P<0.01). 5.The number of CEC, as well as GMP140.was adversely correlated to PaO, (r=-0.9234, P<0.01) and SOD(r=-0.8634, P<0. 01) , and it was positively correlated to LPO ( r=0.8564, P<0. 01) .There were positively correlation between CEC and GMP140 (r=0.7591, P<0.05).Conclusions: Yi Qi Huo Xie herbs in treating chronic cor pulmonale displays extraordinary effect by balancing the oxidation and antioxidation and curing the damane of pulmonary endothelial cells and activated platelets.