The Study Of Medium And Long-chain Intralipid On Hepatic Cirrhosis Patient Fat Tolerance

Objective To study the influence of medium and long-chain intralipid on hepaticcirrhosis patients. Methods Sixteen hepatic cirrhosis patients were randomly assigned to two PN groups:long-chain triglyceride group (LCT), (n=8) and medium-long chain triglyceride group (MLCT), (n=8).Each group was given the same energy of non-protein energy and nitrogen. Fat energy in LCT group was supplied by 20%-lntralipid; group MLCT was supplied by 20% litovenoues. The ratio of glucose to fat is 2 to 1. All patients were treated with PN for 3 days. Results (1) The elimination half-life of LCT was at a lower level as compared with MLCT group (P<0.05); (2) The concentration of octanic acid and capric acid increased slightly and could be detected after intravenous infusion. The level of other time points wear lower than the limit of quantitation; (3) The concentration of p-hydroxybutyratic acid (P-HBA) in MLCT group is higher than that in LCT group. (P<0.01), but p-hydroxybutyratic acid level decreased to the basic value at 90 minutes, but there is no significant change of the level of p-hydroxy butyratic acid in both LCT trial group and control group. That suggested MLCT is the good resource ofketone. Conclusion The cirrhosis hepatic didn't influence MLCT's elimination, MLCT emulsion was eliminated rapidly and may be an ideal energy source for hepatic cirrhosis patients.