Anti-apoptosis Effect Of N-acetylcysteine In Myelodysplastic Syndromes

Objective To investigate the anti-apoptosis effect of N-acetylcysteine in bone marrow progenitors of myelodysplastic syndromes (MDS) in vitro. Methods The apoptosis , clonogenic potential and Tumor Necrosis Factor-α (TNF-α) levels on bone marrow progenitors of MDS dealt with NAC was evaluated separately by using TdT mediated dUTP nick end lableling method, in vitro methylcellulose culture and ELISA method. Results NAC significantly reduced apoptosis, enhanced CFU-GM and decreased TNF-a levels. Conclusion This study shows NAC may play a role in reducing apoptosis and guaranteeing MDS cell survival. Therapy of NAC could be used in MDS patients.