Study On Selecting Of Sensitive Index And Benchmark Dose Of Adverse Effect By Occupational Lead Exposure

Lead is one of the most important materials in industry and seriously unwholesome to occupational population. Meanwhile, it makes adverse effect on human health for its undecomposable nature leads to long-term existence in the environment. This study firstly surveyed the effect of lead on neural system, renal tissue and haemal tissue; and then applied the benchmark dose approach to determine critical concentration of blood lead which led to adverse effect on neural system, renal tissue and haemal tissue in occupational lead exposure and to seek the foremost sensitive index of them.In this survey, the 134 lead-exposed workers came from one storage battery factory. Control group was made up of 26 workers from one mechanical factory and 26 students from one school. The surveying results by occupational epidemiology indicated that occupational lead exposure led to adverse variations of neurobehavior, renal function and haemal tissue. Blood lead level reasonably reflected the effect of lead on neurobehavior, renal function and haemal tissue. In order to study comprehensively the effect of lead on neurobehavior, the result of factor analysisdisclosed concealing common factors of the effect of lead epxosure on neurobehavior. The result of multiple stepwise regression analysis showed the main factors affecting on neurobehavior of lead-exposed workers and the effect of blood lead on neurobehavior was confirmed also. The results that pomsD, pomsV and PAE were critical indexes that test neurobehavior of lead-exposed workers were illustrated by discrimination analysis. Analysis of renal function indexes showed urinary N-acetyl- -D-glucosaminidase(NAG) might be used as an earlier biomarker that occupational lead exposure led to renal injury.This study employed the results from occupational epidemiology, namely, blood lead level reflected that occupational lead exposure affected neurobehavior, renal function and haemal tissue. This study made blood lead as exposure index and neurobehavioral test indexes, renal function indexes and haemal tissue index as effect indexes. The critical concentration of blood lead that occupational lead exposure led to adverse effect on neural system, renal tissue and haemal tissue were determined by the method of BMD. BMD values of blood lead in neural system, renal tissue and haemal tissue were respectively 21.09 g/d 1, 23.92 g/dl and 25.76 g/dl. Analysing blood lead BMD values of neural system further certified that profile of mood states(POMS) was the most sensitive index in neurobehavioral test, and at same time urinary NAG was more confirmed to be used as an earlier biomarker of renal injury for lead-exposed workers. Toconsider comprehensively respective BMD values of blood lead in different target organs, the disorder of neural system appeared prior to injury of other two target organs, that is to say, POMS of neurobehavioral test was the most sensitive index to monitor health standard of lead occupational population.