The Relation Between The Plasma Concentrations Of N-terminal Pro-brain Natriuretic Peptide (NT-proBNP) And Echocardiographic Indices Of Cardiac Dysfunction In The Population With High Risks Of Cardiac Impairment

ObjectiveIn patients with congestion heart failure the plasma concentrations of N-terminal pro-brain natriuretic peptide (NT-proBNP) correlate to cardiac filling pressures. The aim of the present study was to examine the relation between NT-proBNP plasma levels and echocardiographic indices of in the Chinese population with high risks of cardiac impairment. MethodsWe studied 95 patients (49 male and 46 women; mean age, 58years) who had contacted to the cardiac department of our hospital. Plasma NT-proBNPconcentration were measured by the automated Roche NT-proBNP electrochemiluminescent assay. They were divided into 3 groups after echocardiograph check up: 22 patients without cardiac function impaired ( group A); 52 patients with isolated diastolic cardiac dysfunction ( group B); 18 patients with cardiac systolic and/or diastolic dysfunction (group C). Compared the NT-proBNP concentration of every group. The usefulness of the NT-proBNP concentration to the diagnose of cardiac dysfunction were expressed by the area under the receiver operator characteristics curve (AUC). ResultsThe NT-proBNP mean concentration of group C was very high (3670.37 ± 4723.25pg/ml) significantly vs group A(41.9 ± 52.16pg/ml)or group B(195.97 ± 383.57pg/ml) (each P<0.05).And the NT-proBNP mean concentration of group B was also much higher than group A. But there are much overlap in between group B and group A. For the entire cohort of 95 patients, a NT-proBNP level >348.00 pg/ml was 88.9% sensitive, 97.4% specific for the presence of clinical heart failure. The AUC was 97.1% ( 95% CI : 0.938 to 1.004 ). To detect the isolated diastolic cardiac dysfunction, the AUC was only 64%. ConclusionNT-proBNP measurement were helpful in the detection of the cardiacsystolic dysfunction, and could provide important massage about abnormal LVEF of the patients on admission. A NT-proBNP level <348.88pg/ml was helpful in ruling out left ventricular systolic dysfunction. But large samples were needed to detect the value of the plasma NT-proBNP level in the evaluation of the isolated diastolic ventricular dysfunction.