A Functional MRI Study On The Neural Substrates For Chinese Writing

Background Agraphia is a familiar neurological disease in clinic ,but its'pathological substrates was uncertain as yet because common MRI wasn't found organic lesion.The research to normal write center play a important role in revealing it's pathological substrates.Objective Using functional magnetic resonance imaging (fMRI),to reserch brain regions crucial to the process of the Chinese writing.Method Ten right-handed healthy, native volunteers were scanned at 1. STesla magnetic resonance imaging scanner while they were performing three visually instructive task: (1)reading silently Chinese characters, (2)complex finger tapping, (3) copying Chinese characters.Image data were co-registered to correct head motion, spatial nomalized and deconverlutionanalysis,et al. Functional activate maps for copy minus read silently and copy minus finger tapping were generated respectively.The brain regions commonly activated in these two maps were detected and defined as "write center" that motor and language was excludedResult Our main finding was that such common activation was observed in both parietal and frontal lobe, include left middle frontal gyrus,both of medial frontal gyrus , superior parietal lobule and inferior parital lobule, and left precentral gyrus , left postcentral gyrus.Conclusion Chinese writing is a coordinate process of both hemispheres and right hemisphere play a very important role in the Chinese writing. Plenty of cortical and subcortical structures is involved in writing.Using functional magnetic resonance imaging can reveal their role in writing.