Expression And Significance Of Ki67 And P16 In Adrenocortical Tumors Tissue

Objective To study the relationship between Ki67 P16 and adrenocortical tumors. Methods The Labeling Index(LI) of Ki67 and PI6 was detected by immunohistochemical staining in 54 cases of adrenocortical carcinoma(6 cases), adrenocortical adenoma(39 cases) and normal adrenocortical tissue beside tumor(9 cases). Results There is the highest expression of Ki67 and the lowest expression of PI 6 in adrenocortical carcinoma. There exist negative correlation between the expression of Ki67 and P16(r=-0.6722, P<0.05). There is significant difference in the LI of Ki67 and that of P16 between adrenocortical carcinoma and adrenocortical adenoma (P<0.001 ). The cutpoint of LI of Ki67 was 4% and the cutpoint of LI of P16 was 12% in adrenocortical carcinoma . Conclusions The LI of Ki67 above 4% and LI of P16 below 12%, is a sensitive indicator of adrenocortical carcinoma. It is suggested that combine detecting the expression of Ki67 and P16 may be taken as one of biomarkers for differentiation of adrencortical adenomas from adrencortical carcinomas .