Expression Of Epidermal Growth Factor Receptor And Ki67 In The Colorectal Tumors

Objective: To value the relevance of expressions of epidermal growth factor receptor(EGFR) , Ki67 in different histological types of colorectal tumors. Methods: EGFR , Ki67 were detected by immunohistochemistrical SP method in 115 cases of colorectal polyps (inflammatory polyps) ,adenoma and adenocarcinoma confirmed by endoscopy and pathologic diagnosis,and the results were analyzed statistically. Results: EGFR expression was mainly located in cell membrane, Ki67 expression was mainly located in nucleus. The positive rate of EGFR in colorectal polyps, adenoma and adenocarcinoma were 38.09%,71.86%,74.19%,respectively; The positive rate of Ki67 in colorectal polyps, adenoma and adenocarcinoma were 14.29%,53.13%,93.55%.The differences of EGFR expressive intensity were significant between colorectal polyps and adenoma (X~2=6.006,P<0.05) .The expressive intensity was no significant difference between adenoma and adenocarcinoma (X~2=0.061,P>0.05). The differences of EGFR expressive intensity were obviously significant between colorectal polyps and adenocarcinoma (X~2=9.123,P<0.01) .The differences of Ki67 expressive intensity was significant between colorectal polyps and adenoma(X~2=6.501,P<0.05),and were all obviously significant between adenocarcinoma and adenoma , colorectal polyps (X~2=18.768,46.22; P<0.001,0.001 ) .Linear positive correlation was not found in adenocarcinoma between the expressive intensity of EGFR and Ki67(r=0.505,P=0.495). The positive rate of EGFR in tubular adenoma and tubulovillous were 98.3% , 70.4% respectively.Whereas the positive rate of Ki67 in tubular adenoma and tubulovillous were 78.6%, 70.4%,respectively.The expression of EGFR and Ki67 in those two types were of no significant difference(P>0.05).The expressions of EGFR and Ki67 were high (>60% ) in all types of adenocarcinoma. Conclusion: The expressions of EGFR, Ki67 have no significant relevance with polyps; the positive expression of EGFR may be no use in diagnosing colorectal cancers; whereas the positive expression of Ki67 may be...