Analysis Of Risk Factors For Pulmonary Thromboembolism

Objective: To identify independent risk factors for pulmonary thromboembolism and to estimate the magnitude of risk for each.Methods: Seventy-one patients with pulmonary thromboembolism and 71 sex and age matched partial patients and healthy controls were recruited in this study. All patients were diagnosed by lung ventilation /perfusion scan and /or spiral CT as well as medical history. DVT was documented using ultrasonography or CT venography. In the patients and controls, epidemic data such as age, sex, smoking, VTE family history, past episode history, trauma /fracture, deep venous thrombosis(DVT), stroke, malignant tumors, chronic heart and lung disease , diabetes , hyperten-sion , vein varicose /phlebitis were inquired .At the same time ,trauma /fracture ,hypertension chronic heart and lung disease ,diabetes ,vein varicose /phlebitis were controlled .After a 12-hours fast .All the subjects were measured blood routine, triglycerides, cholesterol, AT-III, fibrinogen plasminogen. T-test was used to compare the mean. X2-Test was used to compare the ratios. Logistic regression analysis was used for a multivariate adjustment for other potential confounding factors. Two tailed P-values of 0.05 or less were considered statistically significant.Results: Independent risk factors for VTE included deep venous thrombosis (OR 44.427; 95%CI 10.105-195.317, P<0.05 ,operation(OR 3.407; 95% CI 1.042-11.136, P< 0.05) .fibrinogen (OR 1.717; 95%CI 1.250-3.569, P<0.05), cholesterol (OR 1.678; 95%CI 1.287-3.672, P<0.05), Plasminogen (OR ,1.022; 95%CI 1.000-1.121, P< 0.05), Smoking index (OR, 1.003; 95%CI 1.001-1.006, P<0.05). Conclusions: deep vinous thrombosis, operation, fibrinogen, cholesterol, plasminogen, smoking are independent and important risk factors for VTE.