The Clinical Study Of The Protective Effect Of Ligustrazine On The Pulmonary Dysfunction After Cardiopulmonary Bypass

Objective:.To study the protective effect of pulmonary perfusion with hypothemic protective solution of Ligustrazine on the pulmonary dysfunction after Cardiopulmonary Bypass(CPB).Methods: 32 rheumatic heart disease patients were randomly divided into the study group (n=11), the control group(n=11) and the blank group(n=10). There was no obvious difference between the three groups in sex, age, weight, symptom, the duration of the disease and the time of aortic crossclamp. After the crossclamp was closed, the pulmonary artery was perfused with 4D protective solution of Ligustrazine in the study group and with 4D lactated Ringer's solution in the control group but with no perfusion in the blank group, half dosage was perfused again before crossclamp was released. The plasma Maleic Dialdehyde(MDA) , Superoxide dismutase(SOD) concentrations of the pulmonary vein were measured at the beginning of the operation, before and 10 minutes after the crossclamp was released, before the end of the operation, and those of peripheral vein were measured at the time of 0, 6,12 hours after the operation. The peak airway pressure was measured before the operation and at 0,3,6,12 hours after the operation. Meanwhile, the lung function was also measured.Results: 1. The plasma concentrations of MDA decreased, while that of SOD increased at every time point after the aorta was clamped in three groups, the degree of the changes is in a positive correlation with the time of aortic crossclamp(P<0.05); 2. The plasma concentrations of MDA at every time point after the aortic crossclamp in the study group were lower than that both in the control group and the blank group;(P<0.05); The plasma concentrations of SOD at every time point after the aortic crossclamp in the study group were higher than that both in the control group and the blank group, (P<0.05); 3. The increase of the peak airway pressure in study group were significantly lower than that in the control group and the blank group (P<0.05); 4. The alveolar-arterial oxygen pressure difference(P[A-a]O2), spiro-index and the oxygenation index in the study group were better than that in the control group and the blank group (P<0.05).Conclusion: CPB could result in pulmonary dysfunction, which could be alleviated by pulmonary artery perfusion with the hypothermic protective solution of Ligustrazine. Thus the postoperative lung function was improved.