Clinical-Epidemiological Study On Antihypertensive Efficacy Response To Benazepril Treatment

objects: study the relationship between the 24 hours urinary ions(Ca, Na, K, Na/K) and baseline blood pressure (BP) and response to Benazepril among essential hypertension (EH) patients. Methods: Prospective cohort study was used to investigate the BP change after 15 days' antihypertensive treatment and relative clinical and epidemiology characters among 921 EH patients at A county hi Anhui province. Result: No significant difference was found when single factor and multifactor analysis were used to study the baseline BP and urinary ions. There is no significant difference between the urinary ions distribution in males and that in females. Female patients have better response then male patients after 15 days treatment and the difference is statistical significant. In female patients, there is a relationship between the BP decrease after 15 days treatment and urinary Na/K ratio. When the Na/K ratio was increased one more, the SBP drop would increase 0.5mmHg (se=0.18), and the DBP drop will increase 0.3mmHg (se=0.12). There is a significant relationship between the urinary Ca and SBP decrease after treatment. After ranking the patients into 4 levels according to Ca and Na/K, multifactor linear regression analysis was used, and no significant dose-response relationship was found between Ca and the BP drop both in female and male patients. In female patients, with the increase of the urinary Na/K ratio level, the decrease of SBP and DBP significantly increase, there has significant dose-response relation. But there is no significant difference between the treatment effect and Na/K ratio by logistic regression. Conclusion: People should be suggested to decrease Na intake and ensure enough K and Ca intake. Urinary Ca and Na/K ration have relationship with the BP drop after the treatment of Benazepril in female hypertension patients, and there is significant dose-response with Na/K ratio and BP drop. So , Urinary Ca and Na/K might be valuable factors to forecast response to Benazepril treatment.