The Influence Of Low Sodium Diet On The Efficacy Of Antihypertensive Drugs-A Comparison Test Of L-amlodipine And Benazepril

Objective:Therapeutic effects of two antihypertensives, calcium channel blockers and angiotensin converting enzyme inhibitor, has been observed in essential hypertension by low sodium salt diet.Subjects and Methods:Light-moderate essential hypertensions were selected for 24h urinary sodium measurement. Those whose 24h urinary sodium≥120 mmol are grouped into high sodium group; those whose 24h urinary sodium<120 mmol into lower sodium group. Other general conditions of the two groups were matching.High sodium group:30 patients, with primary mild-moderate hypertension,24h urinary sodium≥120 mmol, were given benazepril tablet treatment of 4W, and then transferred to L-amlodipine with oral treatment 4W.Low sodium group:30 patients, with primary mild-moderate hypertension,24h urinary sodium<120 mmol, were given benazepril tablet treatment of 4W, and then L-amlodipine with oral treatment 4W.Before drug treatment, and after benazepril 4W and L amlodipine treatment 4W, blood pressures of both groups were measured, and parallel 24h ambulatory blood pressures were also measured. Results:1. The pre-medical treatment blood pressure of the low-sodium diet group is lower than that of the high-sodium diet group, the difference was statistically significant (P<0.05).2. High sodium diet group, L-amlodipine antihypertensive effect turns to be better than benazepril The difference was statistically significant (P<0.05). For the Low-sodium diet group, two antihypertensives effects are close, thus the difference was of no statistic significance (P> 0.05).3. After L amlodipine treatment, the final blood pressure of both groups were similar, thus the difference was not statistically significant (P> 0.05); after treatment with benazepril the final level of blood pressure reached the horizontal, and low-sodium diet group works better than the high-sodium diet group, thus the difference was statistically significant (P<0.05).Conclusion:1. Low-sodium diet is helpful to enhance the effect of antihypertensive drugs.2. In the high sodium diet, compared with benazepril (angiotensin-converting enzyme inhibitor), amlodipine L(calcium channel blocker) can reduce blood pressure more effectively. 3. The blood pressure decreasing effect of amlodipine L (Calcium channel blocker) is not affected by salt intake.