Relationship Between The Changes Of Serum Free Fatty Acids And Insulin Resistance In Patients With Impaired Glucose Tolerance

Objective To investigate the changes of serum free fatty acids (FFA) and the relationship between FFA changes and insulin resistance(IR) in the patients with impaired glucose tolerance (IGT). Method The levels of fasting serum total FFA and each elements were measured by gas chromatography technology in 50 cases of patients with IGT. The amounts of fasting plasma glucose ( FPG) and insulin (FINS), triglyceride, total cholesterol, 2h plasma glucose and insulin after oral glucose tolerance test were also assessed at the same time. The insulin-sensitive index(ISI) was obtained by this formula: ISI=1/(FPG · FINS). 40 cases of normal People were recruited as control group. Result The levels serum total FFA,C16:0,C18:0,C18:1(P<0.01) and C18:2(p < 0.05), the amounts of triglyceride, total cholesterol, FPG, FINS, 2hPPG (P < 0.01 ) and 2hPINS ( P < 0.05) weresignificantly increased and their ISI was remarkably decreased ( P < 0.01 ) compared with those in control group. Linear correlation analysis showed that the level of FFA was negativelyCorrelated with ISI (r=-0.784, P<0.01). Conclusi on The higher level of FFA in patients with IGT is related with IR and caused by insulin that does not " have the ability to regulate the level of FFA, may be one of reasons of IR.