Relationship Between The Plasma Total Bilirubin Levels And Severity Of Coronary Stenosis

Objective To investigate the relationship between the plasma total bilirubin levels and severity of coronary artery stenosis.Methods 504 patients who underwent coronary angiography were included in the study and divided into two groups according to severity of coronary artery stenosis: Patients with coronary stenosis ≥ 50%were include in the group of coronary artery disease (CAD) and patients with normal coronary artery or stenosis < 50% were used as controls. Plasma total bilirubin, tolal cholesterol (TC) , triglycerides (TG) , lower density lipoprotein cholesterol(LDL-C), high density lipoprotein cholesterol(HDL-C)were determined in all patients. Coronary atery stenosis was measured by angiographic imaging manipulation system. The severity of CAD was quantified in a modified Gensini score. After the influences from other risk factios of CAD were controlled by statistical Method, the ralationship between plasma total bilirubin levels and severity of CAD was analyzed.Results Plasma total bilirubin in patients ( 1 1 .57 ± 4.67μmol/L) with CAD is statistically significant lower than those in the controls(15.21±5.66 μ mol/L, P<0.0001 ) , More case of CAD were found in group (86.8%) with its total bilirubin in the lower portion of the reference interval than those in the group (65.0%) with its total bilirubin in the upper portion of the reference interval (X2=33.5 P<0.005 ) , Plasma total bilirubin in male -were significantly higher than those in famale in both group(P< 0.0001 ) .Total bilirubin levels inversely associated with the risk of CAD by analysis of multivariate logistic regression model. Regression coeffieient was -0.146 (OR 0.859 giving 95% confidence limits 0.817 to 0.904).Partial correlation analysis showed that plasma total bilirubin was one of the independent risk factors for CAD. Multiple regerssion analysis indicated that plasma total bilirubin was positively correlated with CAD (P< 0.0001).Conclusion The above results suggest that the plasma total bilirubin levels is inversely associated with the prevalence and severity of CAD, it may be one of the predictors for severity of CAD.