Clinical Study Of The Levels Of Total Bilirubin To Predict Coronary Plaque Stability

Objective Previous studies have reported serum that total bilirubin levels were inversely correlated to the prevalence of CAD. However, the relationship between serum levels of bilirubin and coronary plaque stability has not been investigated yet all over the world. The purpose of this study was to examine whether serum bilirubin levels predict coronary plaque stability in patients with CAD by using intravascular ultrasound.Methods Seven-five coronary heart disease (CHD) patients were divided into acute coronary syndrome (ACS) group (n=40) and stable angina pectoris (SAP) group (n=35) according to condition of patients, and 40 non-CHD subjects served as normal control (NC) group. Coronary angiography was undergone in all subjects, among whom the patients with CHD had a further detection with intravascular ultrasound (IVUS). Serum levels of bilirubin in all subjects were measured before operation. The stability of coronary plaque was compared between ACS group and SAP group, and the relationship between serum levels of bilirubin and feature of coronary plaque was analyzed in three groups.Results The serum levels of total bilirubin, direct bilirubin and indirect bilirubin in ACS group were significantly lower than those in SAP group and NC group (P< 0.05); IVUS indicated that lumen area and fibrous cap thickness in ACS group were significantly lower than those in SAP group, whereas plaque burden, size of lipid core, eccentricity index and remodeling index were significantly higher than those in SAP group (P< 0.01); The levels of serum total bilirubin were positively with fibrous cap thickness (r=0.306, P<0.01), while were negatively associated with lipid core, eccentricity index and remodeling index (r =-0.315,-0.324 and -0.310 respectively, P<0.01).Conclusion Serum total bilirubin, as a hematological indicator to predict the coronary plaque stability of CHD patient, is positively associated with coronary plaque stability.