| Objective: Cardiac AT1 is important receptor of regulating myocardium function. In order further to identify whether the autoantibody against the AT1 is related to acute myocardial infarction (AMI) and to observe change in AT1 autoantibody during the development of AMI.Methods: 40 were patients with AMI and 61 were healthy donors .The synthetic peptide corresponding to amion acid sequence 65-191 of the second extracellular loop of the AT1 receptor was used as the antigens .Sera from the patients within the early 24 hours , 7 days and after 2-4 weeks after AMI, AT1 -receptor autoantibody was detected by SA-SEISA. Compared with 61 healthy blood donors as a normal control (NC).Results: (1) The positive rates of the autoantibodies against AT1 -receptors in patients with AMI in the first 24 hours were 17.5%, comparing with NC(13.1%), there was no significance (P>0.05) ;(2)In the later phase (7 day), The positive rates of the autoantibodies against AT1 -receptors 20.0%, which was not significantly higher than NC (P>0.05); (3)The frequencies of the autoantibodies against AT1 -receptor in patients with AMI between 2 to 4 weeks were 40.0%,being significantly higher than NC (P<0.01) and that of patientswith AMI in the first 24 hours .Conclusions: There are autoantibodies against the -receptor in normal human . The positive rates of the autoantibodies against AT1-receptor in the patients with AMI in 24 hour and 7 days were no higher in NC. The frequencies of the autoantibodies against AT1 -receptor were higher in patients with AMI between 2 to 4 weeks. It is suggested that autoimmune mechanisms are involved in AMI. The autoantibodies against the AT1-receptor might be related to the cardiac structural and functional changes.
|
PDF Full Text Request