| Purposes: To study expression of p73α, p53, p21 and their clinical significance in breast carcinoma. Methods: The expression of p73α, p53, p21 was detected by immunohistochemistry in 41 breast carcinoma tissues,13 breast fibroadenoma tissues and 8 normal breast tissues. Results: ①P73αpositive expression rate in breast carcinoma group was 48.8% (20/41) ,p53 positive expression rate was 48.8%(20/41),p21 positive expression rate was 78%(32/41) ;the positive expression rate of p73α,p53,p21 in breast carcinoma tissues was significant higher than in breast fibroadenoma tissues and normal breast tissues. ②P73α expression displayed a positive correlation with p53 instead of p21.③Significant association was observed among the positive expression of p73α and tumor with lymph node metastases, TNM stages of the cancer ; p53 expression was significantly associated with a high histological grade ; p21expression was significantly associated with a low histological grade and tumor without lymph node metastases. The clinical prognosis of p73α(﹣)p53(﹣),p73α(﹣)p21(﹢)group is better than other groups.Conclusion: ①These results suggest that there is up-regulation of p73α in breast carcinoma tissues and up-regulation of p73α may be implicated in the tumorigenesis of breast carcinoma as a molecular alteration..Up-regulation of p73αmay be taken as an index of the clinical prognosis of breast carcinoma.②There is mutation of p53 gene in breast carcinoma. P53 protein may be taken as an index of differentiation degree of breast carcinoma cells.③P21 protein may be used to assess differentiation degree of breast carcinona cells, and potentiality of metastasis of breast carcinoma. ④The combinating detection of p73α,p53,p21 expression may assess the clinical prognosis of breast carcinoma. |
