The Study Of Changes Of Serum Vasopressin,Prolactin And Nitricoxide In Patients With Cerebrovascular Disease

Objective:To find out the clinical value of changes of AVP, NO and PRL in serm in different periods,intracranial pressure,area of infarction and different volume of hemorrhage in patients with cerebrovascular disease.Methods: Choice 50 cases with infraction, 50 cases with hemorrhage and 30 comparative cases. All cases were measured the intracranial pressure. The diagnoses of cases were in accordance with the criterion of cerebrovascular disease in 1995, without other serious physical disease. They were divided into two groups according period after onset: acute phase: 1 hour – three days after onset ; recovery phase: > 21 days after onset. According to different levels of consciousness and muscle power ,They were divided into lightly group and serious group . They were divided into two groups by different CFP(CFP>2.05kpa; CFP<2.05kpa).The patients were divided into three groups according the result of CT: large infraction zone ; multitudes of infraction zones and small infraction zones. The patients were also divided into three groups by volume of hemorrhage. ( <20ml; 20～40ml; >40ml). Results: The levels of NO, PRL, AVP with ACVD were higher than comparative group (p<0.05), which were closely correlated with progressing time,infraction rang of CI,volume of hemorrhage and the clinical prognosis. The levels of NO, PRL, AVP in most of patients with CH, CI be down to normal in recovery phase. While The level of AVP in a few infracted cases with dysnosia was lower but PRL was higher than comparative group conversely. Conclusions:1. The levels of AVP, NO, PRL increased in ACVD, and were closely correlated with severity of illness, the length of period after onset, ICP, area of infraction and volume of hemorrhage. They may involed in the pathophysiology of brain damage after CI, CH .The changes could be as reference criterion of severity and clinical prognosis. 2．AVP was lower than normal and PRL continued to high level in vascular dementia patients in recovery phase. It is seemed to relate to the pathophysiological processes of VD and these cases might be treated and prevented by AVP or DA.3．The increasing of plasma level of AVP, NO, PRL in ACVD and the damage to brain suggested that those cases may be cure by iNOS-inhibitor, nNOS-inhibitor, AVP-receptor-antagonist, PRL-receptor- antagonist and the monoclonal antibody of them .