The Study Of Clinicopathology, Immunophenotypes And Epstein-Barr Virus Infection In Intestinal T-cell Lymphoma In GuangXi

Objective: To investigate intestinal T-cell lymphoma for itsclinicopathology and immunopenotypes features, the relationships between intestinal T-cell lymphoma and Epstein-Barr virus. Methods: Immunohistochemistry studies were performed using polyclonal antibodies CD3 and monoclonal antibodies CD45RO, CD43, CD56, GrB and LMP-1. Results: (1) The ITCL is rate accounting for 2.6% of all the malignant lymphomas, 5.95% of all the T-cell lymphomas and 28.57% of all the intestinal non-Hodgkin's lymphomas in the same period. The positive rate of CD3, CD45RO, CD43 and CD56 were 87.5%, 93.8%, 56.3% and 31.3%, respectively. The positive rate of CD3 and CD45RO at same time is 81.25%. Tumor cells did not express antigens of B lymphocyte. (2) The positive rate of GrB was 50%. (3) The positive rate of LMP-1was 31.25%. Conclusions: These data suggest (1) CD3 and CD45RO can be used as the most sensitive peculiar markers for identifying intestinal T-cell lymphoma, but must use it at same time. CD43, CD56 and GrB may be used as additional markers. (2) EBV latent infection is present in ITCL in Guangxi, EBV may play a role in the development of ITCL.