Serum Levels Of VEGF, BFGF And CRP In Patients With Stable Coronary Artery Disease: Association With The Severity Of Coronary Atherosclerosis And Coronary Collateral Development

Objective To study the correlation of serum vascular endothelial growth factor(VEGF), basic fibroblast growth factor (bFGF) and CRP with the severity of coronary atherosclerosis and coronary collateral development in patients with stable coronary heart disease(SAP)Methods Subjects included 82 patients undergoing diagnostic coronary angiography, 20 of whom had normal coronary arteries (control group). The lesion severity of the remaining 62 patients(CHD group) with stable coronary heart disease demonstrable coronary atherosclerosis(vessle stenosis≥50%) were evaluated by the Gensini scores and the number of significantly lesion coronary vessles. Two groups were divided according to Gensini scores, namely mild atherosclerosis group(Group A,n=29,Gensini score＜30)and severe atherosclerosis group(Group B, n =33, Gensini score ≥30). And the angiographic coronary collateral scores were noted by Rentrop Class. Blood samples were taken before angiography , and levels of serum vascular endothelial growth factor(VEGF),basic fibroblast growth factor(bFGF) and were measured by enzyme-linked immunosorbent assay(ELISA). These levels were then compared between groups.Results Serum vascular endothelial growth factor(VEGF),basic fibroblast growth factor (bFGF) and CRP in CHD group were significantly higher than the control groups(P<0.01).Serum VEGF ,bFGF and CRP level in 2 or 3 vessels lesion group and Gensini score group B were elevated as compared with that of 1 vessel lesion group and and Gensini score group A group respectively(P<0.01). Serum bFGF and CRP level in 3 vessels lesion group and Gensini were higher than 2 vessel lesion group (P<0.05).Both the serum VEGF and bFGF concentrations were positively correlated with the Gensini score(r=0.548,P=0.0100 vs r=0.289, P=0. 0240 respectively). The mean serum VEGF and bFGF concentration was higher in patients with collateral circulation than in those patients without collateral circulation(P<0.01).The collateral circulation occurrence rate in 2 or 3 vessle disease group was higher than that of 1 vessle disease. Conclusion The serum VEGF , bFGF concentration had correlation with the severity of coronary atherosclerosis and coronary collateral.CRP had certain relation with the severity of coronary atherosclerosis. VEGF and bFGF might enhance lateral circulation development and doubtly regulate the development of atherosclersis.