The Relation Between The Stage And Cell Grade And Recurrence Of Bladder Transitional Cell Carcinoma And The Expression Of PTEN And Focal Adhesion Kinase

Objective To study the expression and clinical significance of PTEN and FAK in bladder transitional cell cancer. Method The expression levels of PTEN and FAK in 96 cases of bladder cancer were detected by strepravidin-peroxidase immunohistochemical technique Results The positive expression rates of PTEN were as follows:Ta-l 71.43%(30/42), T2-4 37.04%(20/54),P<0.05; Gl-2 48.65%(36/74),G3-4 63.64%(14/22),P>0.05, primary cancer 58.67%(44/75), recurrent cancer 28.57%(6/21) , P<0.05 The positive expression rates of FAK were as follows:Ta-l 47.62%(20/42), T2-4 85.19%(46/54),P<0.05; Gl-2 68.92%(51/74),G3-4 68.18%(15/22),P>0.05, primary cancer62.67%(47/75),recurrent cancer 90.48%( 19/21), P<0.05;PTEN( + ) 52.00%(26/50),PTEN( - ) 86.96%(40/46),P<0.05 . Conclusion The positive expressions of PTEN and FAK are significantly related to the stage and the recurrence of the tumor. PTEN can reduce the expression of FAK.