Clinical Assessment Of Tumor Marker At Lung Cancer Prognosis

[Background] New tendency of tumor therapy is individualizedtreatment, that is every patient has unique and reasonable therapeutic pattern. At present some factors can effect lung cancer prognosis, the major cause is the failure of treatment leading to distant metastasis and relapse. Now the best combination pattern and theory foundation of detecting tumor marker is absent, so investigating the best combination pattern of tumor marker can judge the effect of tumor marker levels at lung cancer and can give exact evaluation of prognosis.[Purpose] Determination tumor marker will do differentialdiagnosis, treatment assessment and prognostic judgement except diagnosis. Exploring the best combination pattern of tumor marker can rise the sensibility and specificity of tumor marker, ameliorate prognosis, rise living quality.[Methods] Through case review and survey analyze tumor markerCEA, NSE, CYFRA21-1, CA125, CA15-3, CA19-9, CA724, SCCs effect on lung cancer prognosis, definite correlation factor of prognosis.[Standards] all lung cancer patients have been confirmated bypathology , all clinical staging, operation or not.[Observation Marker] 1 Correlation investigation of factors whichpossibly influence lung cancer prognosis.2 Further investigating factors influencing lung cancer prognosis and pathology, stage and differentiation all data have been treated by SPSS software.[Test Kit] Test kit is offered by USA Roche corporation.Biochemical department of our hospital use electrochemiluminescence technique detecting serum tumor marker.[Result] 1. The fist detecting time tumor marker rising number andCEA rising rate are the major factors of lung cancer prognosis. We find the first time metastasis mode might have some effect on lung cancer prognosis, is the secondary factor of lung cancer prognosis.2.CA724 rising rate is correlated with lung cancer prognosis. CYFRA21-1 changing rate and CA153 changing rate have some relation with tumor stage. CYFRA21-1 changing rate, CA153 changing rate and CA125 changing rate all have some definit correlation with pathology type.3. The first decting time tumor marker rising number has some relation with tumor stage, has no relation with pathology and differentiation. When the first time tumor marker rising number is 0, tumor marker rising rate has clear correlation with tumor prognosis. The first time NSE rising rate has some corralation with tumor prognosis.[Conclusion] 1 .The fist detecting time tumor marker rising numberis the major factors of lung cancer prognosis. The first decting time tumor marker rising number has some relation with tumor stage, has no relation with pathology and differentiation.2. CEA rising rate also is the major factors of lung cancer prognosis. CYFRA21-1 changing rate and CA153 changing rate have some relation with tumor stage, may provide some reference for tumor stage.3. The first time metastasis mode might have some effect on lung cancer prognosis, is the secondary factor of lung cancer prognosis. 4.These factors break through the limit of tumor marker range, stress tumor marker changing tendency. Clinical practise we may correlate tumor marker rising range and tumor marker changing rate , make ideal judgement of lung cancer prognosis.