Clinical Study On The Effect Of Tiaozhi Zengshou Decoction On Dyslipidaemia

Objectives: To observe the clinical curative effect of Tiaozhi Zengshou Decoction on blood lipids, atheromatous index, non-high density lipoprotein-cholesterol, C-reactive protein and homocystine in patients with dyslipidaemia. To validate it's therapeutical effect on dyslipidaemia and it's preventive and curative effect on coronary heart disease and cardiovascular and cerebrovascular diseases and to assess the safety of Tiaozhi Zengshou Decoction.Methods: The diagnosis standard were "Prevention, detection, evaluation, and treatment of dyslipidaemia" and "National cholesterol education program(NCEP)". Traditional Chinese Medicine differentiation refer to Chen Keji's "Practical internal medicine of combination of TCM and western medicine".There are only 120 patients with dyslipidaemia who have whole data. Patients with their coming order were randomly divided into traditional Chinese medicine group receiving Tiaozhi Zengshou Decoction (n=43), western medicine group receiving Pravastatin Tablet (n=40)禄 traditional Chinese medicine and western medicine group receiving Tiaozhi Zengshou Decoction and Pravastatin Tablet (n=37) . The therapeutic course for each group was 8 weeks. The levels of TC, TG, HDL-c, LDL-c, ApoAI, ApoB100,( TC - HDL-c)/HDL-c, non-HDL-c, Hey and CRP were performed as observingindexes. All indexes were examined at the beginning and the end of treatment At the same time, the patients' liver function, renal function, electrolure, blood sugar, transaminase, routine tests of blood and urine were tested. All these indexes were analyzed to contrast the therapeutical efficacies of each group. The effect of Tiaozhi Zengshou Decoction in regulating blood lipids and adverse effect in patients were observed.Results: The total effective rate of Tiaozhi Zengshou Decoction group was 83.72%. There was no significant difference between Tiaozhi Zengshou Decoction group and Pravastatin Tablet group about total effective rate. The effect of Tiaozhi Zengshou Decoction and Pravastatin Tablet group was more superior than that of the other two groups. After 8 weeks, the levels of TC, TG, LDL-c, (TC-HDL-c)/HDL-c, non-HDL-c and CRP were significantly decreased and the level of ApoAj were obviously increased in Tiaozhi Zengshou Decoction group and Pravastatin Tablet group. The level of HDL-c were significantly increased and the levels of ApoBioo and Hey were significantly decreased in Tiaozhi Zengshou Decoction group. The main syndrome differentiation of dyslipidaemia are stagnant of qi and blood stasis type and phlegm stagnancy type. The main pathogenic factors and pathogenesis of dyslipidaemia are phlegm and blood stasis. The adverse effect of Tiaozhi Zengshou Decoction was better than that of Pravastatin Tablet group.Conclusion: Tiaozhi Zengshou Decoction have definite curative effect in treatingpatients with dyslipidaemia. It can effectively raise the level of HDL-c, decrease the level of ApoB100, prevent and treat cardiovascular and cerebrovascular disease and have little side effects.