Study On The Relationship Of Adrenomedullin, Endothelin And GMP-140 In Patients With Acute Coronary Syndrome

Objective To study the relationship between the acute coronary syndrome and some vasoactive substances, the levels of plasma adrenomedullin(ADM),endothelin-l( ET-1) and a-granule membrane protein( GMP-140) were determined .Methods 60 patients with coronary heart disease were randomly recruited and divided into 3 groups equally: the stable angina pectoris (SAP) group; the unstable angina pectoris/no-ST segment elevation myocardial infarction (UAP/NSTEMI) group; the ST-segment elevation myocardial infarction( STEMI) group. 20 healthy persons recruited as the control group. The levels of plasma ADM and ET-1 were determined by radioimmunoassay; The level of plasma GMP-140 was determined by ELISA. Results The levels of plasma ADM, ET-1, GMP-140 increased significantly in UAP/NSTEMI group and STEMI group compared to those in the control group (t=5.147 ~ 12.220, p < 0.01 ). No differences were found in the levels of plasma ADM, ET-1 , and GMP-140 between the SAP group and the control group (t=0.801 - 1.692,p>0.05).There were statistical differences in the levels of plasma ADM, ET-1 and GMP-140 among the SAP group, the UAP/NSTEMI group, and the STEMI group (t=3.378 ~ 10.910, p<0.01 ). Positive correlations were found among the levels of plasma ADM and ET-1, GMP-140(r=0.884, 0.726; p < 0.01 ) There was positive correlation between the levels of plasma ET-1 and GMP-140(r=0.803,p < 0.01 ). Conclusions (1)ADM, ET-1, and GMP-140 involve in the pathophysiology of acute coronary syndrome.(2)The mutual affection and influence of plasma ADM, ET-1 and GMP-140 play an important role in the development of acute coronary syndrome. (3)The levels of plasma ADM, ET-1 and GMP-140 could reflect the risk of acute coronary syndrome, and could be indicators for the assessment of unstable atherosclerosis.