Tetramethylpyrazine Preconditioning Changes The Release Of Cardiac Troponin I Of Rheumatic Heart Patient In The Pre-and Postoperative Period

Objective:.This articles studys the change of the release of cardiac troponin I during the heart valves replaced after Tetramethylpyrazine preconditioning, To approach Tetramethylpyrazine's preserving the myocardiumMethod: from 2003 year 7 month to 2004 year 4 month 40 patients finally diagnosed as rheumaetic heart disease were randomly divided into the Tetramethylpyrazine group (A group,n=20) and the control group (B group,n=20).The patients of A group were injected with Tetramethylpyrazine(4mg/kg) before operation.the Venous blood samples between two grounps were taken at the following times before using Tetramethylpyrazine, thirties minutes after the aorta blocked, thirties minutes after aorta opened,24 hours 48 hours 72 hours and 150 hours after operation. We measure the concentrations of cTnI,CK,CK-MB and LDH.record the rate of automatical heart ambi-beat. and inotropic agent use after operation complication and information of curingResults: 1.every time point content of cTnI,CK,CK-MB and LDH in the control group was obviously superer than that in the Tetramethylpyrazine group (P<0.01 < 0.05, seen in attached table2) . The sensitivity of cTnI was superer than that of the myocard zymogram 3. the rate of automatical heart ambi-beat is eighty percent in the Tetramethylpyrazine group,but sixty-five percent in the control group,The disparity oftwo groups is significant (P<0.01 0.05) 4.The rate of adrenalin use is five percent in the Tetramethylpyrazine group,but twenty percent in the control group.one was dead after operation in the Tetramethylpyrazine group,three were dead in the control group and two LCOSes happentConclusion: : 1.Plasma cTnI and plasma CK ,CK-MBand LDH levels change obviously. But cTnI is more sensitive these are coincident with other dicuments; 2. Tetramethylpyrazine preconditioning can affect plasma cTnI ,CK ,CK-MBand LDH levels obviousely. But cTnI is more sensitive-, 3. Tetramethylpyrazine can mitigate ischemical reperfusion injury of myocardial cell...