Study On Influential Factors Of Bone Mineral Density For Elderly Man In County

Objective To explore the influential factors of bone mineral density for elderly man in country. The major influential factors of the current study included alcohol consumption, physical activity and calcium intake from food. Methods In order to elucidate genetic and environmental influence on bone mineral density of elder man in country, from January 2001 to October 2001, a study on pharmacogenomics in osteoporosis was conducted in County and suburb of Anqing, Anhui, China. In total, 1,305 elderly man subjects from 582 nuclear family recruited to the study. Bone mineral density was measured by dual-photon X-ray (DPX) absorptiometry , the measurement sites were femoral neck, ward's triangle, shaft and L2-4 spine, epidemiological information was completed by a standard questionnaire. We analyzed the data by methods of multiple linear regression analysis in SAS6.12 software. Results (1) (1) All former smokers andcurrent smokers had a lower bone mineral density at the femoral neck and L2-4 spine than non-smokers. Only current smoker had a significantly reduced BMD at femoral neck (p=0.006) and L2-4 spine (p=0.001 )after adjustment for confounding factors. Comparing with non-smokers, total smoke 25 year*package and total smoke>25 year*package, the bone mineral density at femoral neck reduced 21.98mg/cm2(P=0.017) and 24.65mg/cm2(P=0.007) respectively, the bone mineral density at L2-4 spine reduced 33.51mg/cm2(P=0.002) and 34.92mg/cm2(P=0.002) respectively. (2) Comparing with non-drinking group, the bone mineral density of alcohol drinking at femoral and L2-4 spine increased 16.10 mg/cm2(P = 0.022) and 10.32 mg/cm2(P = 0.201). Comparing with the non-drinking group, the bone mineral density at femoral neck of subjects who drink 72ml/day increased 22.42mg/cm2(P = 0.015), neither 72-150ml/day nor > 150ml/day had a significantly increment. Drinking had no significantly influence for L2-4 spine bone mineral density. (3) Comparing with drinking but non-smoking group, non-smoking and non-drinking group, smoking and drinking group, smoking but non-drinking group had a change of bone mineral density at femoral neck -3.34mg/cm2(P = 0.816), -15.35mg/cm2(P = 0.203) and -31.52mg/cm2(P = 0.010) respectively, the bone mineral density at L2-4 spine had a change respectively is 13.88mg/cm2(P=0.414), -19.68mg/cm2(P=0.132) and -30.06mg/cm2(P=0.032). (4) Load (p=0), drive bicycle (p=0.012) had a significantly positive association and work sitting (p=0.036) had a inverse association with femoral neck BMD for elderly man in county after adjustment for confounding factors. Any physical activity had no significantly effect to L2-4 spine BMD. Comparing to the non-loading group, subjects with loading less than 1 hour and more than 1 hour per day show 22.52 g/cm2 (p=0.003) and 37.14 g/cm2 (p=0) higher in femoral bone mineral density respectively; Comparing to the non-driving bicycle group, subjects with driving bicycle less than 1 hour and more than 1 hour per day show 7.96 g/cm2 (p=0.264) and 18.27 g/cm2 (p=0.044) higher in femoral bone mineral density respectively; Comparing to the non-working sittinggroup, subjects with working sitting less than 2 hour and more than 2 hour per day show 0.31 g,cm2 (p=0.967) and 16.99 g,cm2 (p=0.042) lower in femoral bone mineral density respectively.Conclusion In the present study, we found that for elderly man in county, smoking can decrease their bone mineral density, moderate drinking can increase that, smoking and drinking had a inter-action influence for bone mineral density. We also found loading and driving bicycle can significantly increased femoral neck bone mineral density and working sitting can significantly decreased it elderly man in country.