The Comparison Of The Orchiectomy Adding Total Androgen Blockade With Simple Orchiectomy In Middle And Later Period Prostate Cancer

Carcimoma of the prostate (CaP) is the malignant tumur of Urinary, the incidence of CaP continues to increase with advanced age. In America, the incidence rate of CaP has surpassed pulmonary carcinoma, become the first in male malignant tumur, death rate second only of pulmonary carcinoma. Because of the position of CaP is secluding, it has no strange symptom in earlier period. The patients final diagnosed mostly have lost radical operation occasio. Thus, it is necessary to choose a better therapy method for late CaP in clinical employment. Objective: To study efficacy and necessary of total androgen blockade for prostate cancer. Methods: 40 cases diagnosised prostate cancer according to Whitmore jewett and UICC into: B2 stage 6 cases, C stage 20 cases, D stage 14 cases. They were divided randomly into two groups of simple orchiectomy and orchiectomy plus total androgen blockade. The simple orchiectomy group 12 cases all underwent orchiectomy and didn't eat androgen blockage medicine because of economic reasons or other. 28 cases were treated with orchiectomy plus total androgen blockage. We gave them Flutamide or Casodex 3 times pre-day or 1 times pre-day. We observed their PSA, prostate volume and alive times in two groups after operation. Resuts: 27 cases were given follow up. 8 of them were simple orchiectomy group, 19 of them were orchiectomy plus androgen blockage. Alive rate of the two group are 25.0% and 78.9%. The difference has statistic significance (P<0.05). And the simple orchiectomy has lower life qualities (P<0.05). The PSA levels after operation 3 to 6 months, the simple orchiectomy group is 9.8±4.9ng/ml, the orchiectomy plus androgen blockage is 5.5±2.1ng/ml, the latter is lower (P<0.05). The prostate volume total androgen blockade group were better, and survival time had longer than simple orchiectomy group's after 3 to 6 months. Conclusion: The total androgen blockade were better than the simple orchiectomy to treat prostate cancer. The patients with total androgen blockade were longer survival time than those with simple orchiectomy. It is necessary to take androgen blockade for prostate cancer.