| Diabetes mellitus is one of the diseases with the highest morbidity and mortality in the resent years all over the world. The antidiabetes drugs are of four kinds: sulphonamide derivatives, guanidine derivatives, glucosidase inhibitor and euglycemic agent. Though we can select different kinds of drugs to treat diabetes mellitus, oral antidiabetes drugs have many adverse reaction and toxic effect. In the recent years the research focus on oral antidiabetes drugs is vanadium compound and its effects of reduction in blood glucose. Vanadium plays an important role in growth and development, cardiovascular and renal functions and metabolism. Moreover, the evidence showed that sodium orthovanadate and vanadium oxysulfate have the similar effects of insulin, but we haven't found the report about LMYF.The study's objective is to investigate the effect of LMYF on reducing blood glucose in rats with typeⅡDM induced by steptozocin and discuss the mechanism. Firstly, the typeⅡDM model in Wistar rats was set up, and then the rats were divided into five groups: control group, positive group and treatment group with high, middle and low dose of LMYF. The index of blood glucose, HDL, LDL, TG, CHO and insulin concentration was determined by instruments and the index of blood apparent viscocity including whole blood viscocity, plasma specific viscosity, blood sedimentation, HCT and fibrinogen were observed.The result show that LMYF can decrease the level of blood glucose after drug withdrawal 2 weeks.The HDL and CHO were reduced markly in treatment group with LMYF comparing with control group.The whole blood viscocity was decreased clearly and blood sedimentation was speeded up in treatment group with LMYF comparing with control group.LMYF can diminish the area under the curve of glucose resistance.LMYF can not influence the concentration of plasma insulin.The results that LMYF can decrease markly blood glucose concentration and the level of blood fat and can not influence the plasma insulin concentration demonstrated the mechanism of LMYF to reduce blood glucose is not owning to stimulating the βcells of the pancreatic islets to release insulin but owning to elevating efficiency of insulin. Blood apparent viscocity increasing and red blood cell aggregating are the result of metabolic disorder in DM patients. LMYF can decrease whole blood viscocity clearly and speed up blood sedimentation in wistar rats with typeⅡDM. The data demonstrated that LMYF can amelioration hemorheology and delay the cardiovascular system complications in DM patients. LMYF can reduce HDL and CHO markly in treatment group showed that LMYF influences the metabolism of blood fat. The study found that adverse effects such as diarrhea, decreased food appetite, dehydration and hypoglycemia in group of administrating LMYF are low.In conclusion, LMYF can reduce blood glucose and blood fat. Its long effective duration and the low incidence rate of adverse effects are the advantages of LMYF. The study showed that LMYF probably develops the new promising oral antidiabetes drugs.
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