The Role Of Vascular Cell Adhesion Molecule-1 In Patients With Coronary Heart Disease

Objectives: To study the role of vascular cell adhesion molecule-1 in the cause and development of coronary artery disease, and its relationship with the coronary severity scores and the stability of atherosclerosis plaque.Methods: Serum levels of soluble vascular cell adhesion molecule-1 were measured by enzyme-linked immunoassay; Serum levels of tumor necrosis factor-alpha were determined by radioimmunoassay; Coronary angiography were performed using the Judkins method and the drugs intakes and other risk factors were investigated in all subjects.Results: Serum soluble vascular cell adhesion molecule-1 level in patients with acute coronary syndrome was the highest, followed by patients with stable angina pectoris, and the level of the normal subjects was lowest among all the groups (P<0.05). The acute coronary syndrome patients have the highest serum tumor necrosis factor-alpha levels, followed by patients with stable angina pectoris, and the level in normal subjects was the lowest, but no significant differences were detected. Of the coronary severity scores, no significant differences were found between patients with acute coronary syndrome and those with stable angina pectoris, but the scores of both were higher than that of the normal subjects (P<0.05). The levels of soluble vascular cell adhesion molecule-1 were positively correlated with the coronary severity scores in patients with stable angina pectoris(r=0.429, P<0.05); and the serum high density lipoprotein levels were inversely correlated with the coronary severity scores in patients with acute coronary syndrome(r=-0.375, P<0.05).Conclusions: Soluble vascular cell adhesion molecule-1 was associated with the severity of coronary artery disease and the stability and inflammatory responses of atherosclerosis plaque. It could be used as estimation as well as a risk assessment mark of both situations.