Clinical Analysis Of 108 Cases With Kawasaki Disease

Kawasaki disease is also named as mucocutaneous lymph node syndrome. It is a vasculitis syndrome. Its pathogeny and mechanism still remain elusive. It is reported that the incidence rate of this disease is gradually increasing, especially in U.S.A., Japan and China, and the incidence of heart complications in Kawasaki disease is now becoming the commonest cause of acquired heart diseases in children. It can result in severe coronary artery aneurysm, stenosis, occlusion, myocardial infarction and so on. It damages the health of children severely. Early diagnosis and appropriate treatment can decrease the complications and improve the prognosis. So the approach to diagnosis and treatment is essential.The present study aimed at analyzing the clinical presentation, laboratory inspection and various treatments of 108 cases with Kawasaki disease. The clinical presentation mainly includes the constitutional rate of age, main symptoms and the characteristic change of this disease. To discussion the various treatments of aspirin, intravenous immunoglobulin(IVIG) and corticosteroid. The 108 cases with Kawasaki disease were divided into three groups, and each group was given difference dose intravenous immunoglobulin (IVIG). The results of statistic analysis showed that there is no statistic significant difference between the group of intravenous immunoglobulin (IVIG) 1g/(kg.d) ×1day and 2g/(kg.d) ×1day,but there is statistic significant difference between the group of intravenous immunoglobulin(IVIG) 400mg (kg.d) for 5 days and the front two groups. So in order to not only decrease the incidence rate of coronary artery lesion but also decrease the economic burden of patients. We can choice the optimal dose.By clinical observation and analysis, we can improve our recognition to KD, especially to non-typical KD. So once we meet suspected cases, we should give them early check of UCG. If there is coronary artery lesion, we can diagnose him as KD even though he dose not meet American Heart Association (AHA) criteria and give him IVIG early in order to decrease coronary artery lesion. As to non-typical KD, we should also combine clinical symptoms with laboratory inspections, such as the increase of WBC, PLT, EST, CRP and protein electrophoresis α2 and the decrease of HB, so that we can come to early diagnose and treatment to bring down the coronary artery lesion and meliorate the prognosis. And we should reinforce the follow-up at this disease and observe the long-term consequence of regressed coronary artery lesion and take corresponding measures.