The Study On The Correlation Of Serum Cystatin C And Detector Index In Early Organ Damage In Patients With Essential Hypertension

Objective: To determine the value of serum Cystatin c as a sign of early organ damage in patients with essential hypertension. Methods:Forty-nine patients with essential hypertension were included in this study.The level of Cystatin c in serum, echocardiography (left ventricular mass index,E/A,E peak decreased time), twenty-four hours ambulatory blood pressure(twenty-four hours mean systolic blood pressure,twenty-four hours mean diastolic blood pressure,the day and night mean systolic blood pressure,the day and night diastolic blood pressure, declined rate of night blood pressure,blood pressure stress),the serum creatinine, twenty-four hours urine protein, α1 microglobulin and microalbumin were assessed.The correlations of Cystatin c and the rest index were analysed and stepwise multiple linear regression was carried out.Results:Positive correlation was observed between serum Cystatin c and serum creatinine,left ventricular mass index, α1 microglobulin, microalbumin, 24 hours mean systolic blood pressure ,the day mean systolic blood pressure,the night mean systolic blood pressure,blood pressure stress.Conclusion:Cystatin c may reflect early organ damage in patients with hypertension and is used clinically as detector index.