Association Of Cystatin C And Risk Of Essential Hypertension In Elder Patients With Diabetes

BackgroundSerum cystatin C is the independent risk factor for essential hypertension, meanwhile hypertension is a common diabetic vascular complications in elder patients. We hypothesized that serum cystatin C would be the independentriskfactor for essential hypertension in elder patients with diabetes.ObjectiveTo investigate the relationship between serum cystatin C level and risk of essential hypertension in elder diabetic patients.Methods538 cases of elderly diabetic patients were enrolled from 2013 January to 2014 August in our hospital. All the patients were divided into two groups, non-hypertension group(191 cases) and hypertension group(347 cases) according to the blood pressure. The general clinical data were collected, including age, gender, body mass index(BMI), blood pressure, blood lipid, serum cystatin C, serum creatinine, high sensitive C reactive protein, N terminal B type natriuretic peptide, glycosylated hemoglobin and fasting blood glucose.ResultsCompared with non-hypertension group, age,the case of smoking patients, body mass index, systolic pressure, diastolic pressure were significantly increased in hypertension patients. According to the blood pressure levels in patients, all patients were divided into 4 groups, control group, level 1, level 2 and level 3 patients with essential hypertension. Compared with the control group, age, BMI, systolic blood pressure, diastolic blood pressure, Cystatin C, hs-CRP, N terminal B type natriuretic peptide levels in level 3 hypertension patients were significantly increased. And compared with the control group, the systolic blood pressure, diastolic blood pressure levels were significantly increased in level 1 and level 2 hypertension patients. Compared with cystatin C levels in patients with level 1 hypertension patients, those were significantly increased(P < 0.05). The relationship of risk factors and the incidence of hypertension was determined by spearman’s assay. The results of Spearman correlation analysis suggest that, hypertension were associated with age, smoking history, BMI, SBP, DBP, hs-CRP, creatinine and cystatin C. Multivariate logistic regression analysis demonstrated that age, smoking history, BMI, creatinine, cystatin C and N terminal B type natriuretic peptide levels were the independent risk factors of essential hypertension in elder diabetes patients. The relationship of risk factors and Cystatin C level were also determined by spearman’s assay. The results suggested that the risk factors of plasma cystatin C level in elder diabetes patients mainly include age, gender, smoking history, systolic blood pressure, TC, NT-proBNP, LDL-C, HDL-C,hs-CRP and serum creatinine level.ConclusionWith the increase of serum cystatin C level in elderly diabetic patients, the incidence of hypertension has a rising trend, which may suggest that cystatin C could be an independent risk factor for essential hypertension in elderly diabetes patients.