| Cardiovascular diseases have been become the primary dangerous of our health.Abnormity of structure and function of arterial wall is the pathology-base of it,and change on arterial elasticity(compliance) is one primary behave of this abnormity.Furthermore, changes on arterial elasticity(compliance) play a very important role in occur and development of cardiovascular disease by working on some parameters such as pulse pressure(PP). So, study on arterial elasticity(compliance) become one of the focus of corrent reserching.Diabetes mellitus is a very important risk factor of coronary heart disease,its risk of occur cardiovascular event in 10 years exceed 20% ,therefore diabetes mellitus being regarded as a equivalent of coronary heart disease. Some studies showed that arterial elasticity(compliance) reduced in patients with with type 2 diabetes mellitus.But the mechanism of it hasn't been revealed clearly yet. So it's worthy doing more researches on arterial elasticity (compliance) of patients with with type 2 diabetes mellitus.Endothelium function is the most important factor which working on arterial wall structure and funtion.NO can improve the function of arterial wall rapidly by stretch smooth muscle of artery,so we usually estimate the change on arterial elasticity(compliance) by taking nitroglycerin orally. Recent studies revealed that the reduced arterial elasticity(compliance) is a sensitive marker of Cardiovascular diseases. A reduced systemic arterial elasticity(compliance) that can be derived from analysis of the pulse contour is regarded as the best clinical index of impaired pulsatile auterial function and may mark the presence of early vascular damage. In other words,we can measure and find the changes on arterial elasticity(compliance) before symptom become obvious.Thus we may prognosticate the risk before disease outbreak.(Symptom usually is the later character of the function-changes of organ). So,studies on arterial elasticity(compliance) has great theory and clinic significance.As a non-invasive examination of arterial elasticity (compliance),C1 (large arterial compliance) and C2 (oscillatory compliance ) have been considerd the best parameter to reflect those changes on arterial compliance,especially C2 .Objective:To observe the changes of C1 (large arterial elasticity index) and C2 (small arterial elasticity index) in patients with type 2 diabetes mellitus and healthy subjects and the effect of nitroglycerin on them .Discuss the mechanism of it.Methods:By using CVProfilerDO-2020, C1 and C2 of 65 patients with type 2 diabetes mellitus and 62 healthy subjects were measured .Still ,C1 and C2 of some healthy subjects and diabetes patients were measured after taking nitroglycerin orally. Results: C2 of type 2 diabetes mellitus were significantly lower than the one of the healthy subjects (3.68±2.03 Vs 6.30±2.68,P<0.05), but C1 not(14.4±4.5 Vs 15.3±3.7,P>0.05). After taking nitroglycerin orally , C2 of diabetes patients was obviously increased(6.25±1.99 Vs 3.87±2.11,P<0.05),but C1 not(17.0±5.4 Vs 15.0±4.5,P>0.05). Conclusion: The small arterial elasticity (C2) of patients with type 2 diabetes mellitus was significantly decreased ,which could be reversed by taking nitroglycerin.The endothelial dysfunction might plays an important role during the injuring process of small arterial elasticity in diabetes patients. A reduced C2 (small arterial elasticity index) is more sensitive than C1 (large arterial compliance) to mark the presence of early vascular damage. C2 (small arterial elasticity index) and C1 (large arterial compliance) correlated negatively with pulse pressure(PP). |
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