Expression Of Protein S100A4 And Nm-23H1 In Pancreatic Ductal Adenocarcinoma And Its Clinical Signifinance

Pancreatic ductal adenocarcinoma is the fourth leading cause of gastrointestinal malignant tumor behind colorectal tumor,and which incidence has increased steadily. With its initial silent clinical course but explosive growth,most of the patients (80%) with presentation have been advanced stage when the dignosis is made. So the respectability rate is low(20-30%) which cause its prognosis is very pool. It is important to study the invasion and metastasis of pancreatic cancer to improve its dignosis and treatment. The expression of protein S100A4 and nm-23H1 has been a hotspot to study by many scientists in recent years. We study expression of S100A4 and nm-23H1 in pancreatic ductal adenocarcinoma and its clinical signifinance by using immunohistochemistry. Materials and Methods: A series of 45 well-characterized primary invasive ductal pancreatic adenocarcinomas resected at the Changhai Hospital were selected solely on the basis of tissue availability for pathology. Fifteen pancreatic adenocarcinomas were poorly differentiated, 19 were moderately differentiated, and 11 were well differentiated. Pancreatic tissues from six patients with chronic pancreatitis were also selected for pathology All cases have been confirmed by pathology and have completely follow-up information. We study the expression of protein S100A4 and nm-23H1 in pancreatic ductal adenocarcinoma and chronic pancreatitis tissues by using immunohistochemistry. Results:We found that 21 of 45 pancreatic ductal adenocarcinoma (46.67%) expressed S100A4 protein, whereas tissue affected by chronic pancreatitis did not label. Expression of S100A4 was associated with poor differentiation and metabasis of lymphoid node of the pancreatic adenocarcinomas (P < 0.05). While it was not associated with staging (P>0.05).The cases which espressed S100A4 protein have a more better prognosis. We also found that 24 of 45 pancreatic ductal adenocarcinoma (53.33%) expressed nm-23H1 protein, whereas tissue affected by chronic pancreatitis also did not label. Expression of protein nm-23H1 was associated with poor differentiation and metabasis of lymphoid node of the pancreatic adenocarcinomas (P < 0.05),and was not associated with staging (P>0.05).The cases expressed nm-23H1 have a more better prognosis,too. And we found expression of protein S100A4 was not associated with the nm-23H1 (P>0.05).The prognosis of cases expressed both S100A4 and nm-23H1 protein is the worst.(P<0.05). Conclusions: S100A4 and nm-23 plays a important role in the growth progression, invasion and metastasis of pancreatic ductal adenocarcinoma and may serve as prognostic markers and that the overexpressin of both factors may creat an environment that enables pancreatic cancer cells to invade surrounding tissues.