A Meta-analysis On Randomized Control Trial Of Carvedilol And Labetalol Treatment In Mild And Moderate Hypertension

Objective: To evaluate the differences in therapeutic effects and safety between carvedilol(Ca) and labetalol(La). Methods: All the papers of randomized control trial about the treatment of carvedilol and labetalol on patients with mild and moderate hypertension. Meta-analysis was performed by using the statistical software RevMan4.1 on the basis of strict quality evaluation on seven trials of randomized control trial. Two different models, namely, fixed effect model and random effect model, were applied to analyze the results. Results: The significantly difference in pooled effect of efficiency rate of carvedilol and labetalol on patients with mild and moderate hypertension: Z = 2.08, P = 0.04, The combined OR was 1.53(95%CI, 1.03 to 2.29), sensitivity analysis suggested that the results have a good reliability. No significant publication bias has been found. Significant difference of different value of diastolic pressure in pre- and after treatment between two drugs has been found(Z = 3.02, P = 0.002), WMD = 1.65(0.58, 2.71), No significant difference of different value of systolic pressure and heart rate in pre- and after treatment between two drugs has been found. Conclusions: Compared with labetalol, total effective has been enhanced, has significant effective in decompression; But the design of the civil studies reported is not entirely science-oriented.