| In mid-trimester induction of labor,The traditional method of intraamniotic administration of ethacridine lactate was applied widely because of high rate of success(about 98%) ,simple technic, low cost and killing the fetal.But it also has shortcoming such as evoking un-coordinated uterine contraction prolonging duration of cervical dilate or labor stage and high rate of retained placenta.In recent years the method of mifepristone combine misoprostol provided a good method not to inter- uterine。According the report the rate of success was descent with the age of pregnacy increasing.In china, there are still some other method such as applying snakegourd root ,castor oil etc,were not widely applied in clinical bcause of serious side-efect and poor acceptability. A retrospective study of women undergoing pregnancy termination between 16 and 28 weeks gestation from 2001/11/16 to 2004/5/16. One hundred and forty two patients with poor cervical condition in whom one of three termination methods were used were assessed Objective:To compare the efficacy and security of methods of mifepristone and misoprostol combine with warter bag for mid-trimester pregnancy termination. Method: Totalamount 122 women who voluntarily undergoing pregnancy termination between 16 and 28 weeks gestation from September 2001to Desember 2003 were applied one of three methods in our hospital respectively (i) oral mifepristone, misoprostol combine water bag insertion (MMW 40patients).(ii) rivanol Intra-amniotic injection (RII 52 patients) (iii) oral mifepristone, misoprostol(MM) (50 patients). According to majority documents report, patients in whom abortion was not obtained within 72 hours in group MMW with the water bag insertion or in group RII with rivanol Intra-amniotic injection. within 48hour in group MM with the primary misoprostol administer were registered as failures. foetus and placent expulsion completely were registered complete abortion. Partial placent and decidual fragments remain were registered uncompletely abortion. We adopt this standard also.Result:The duration from induction to labor was shorter in MMW group(18.87±7.48h) than RII group(39.34±9.31h) (t=11.09 P>0.005). The difference was significant between tow groups,(t=11.09 P>0.005).No significant difference between MMW group and MM group,(t=0.79212.05 ) Total stage of labor was shorter in group MMW than in group RII, the difference was significant (t=3.9988>t(0.001) P<0.001) .In the cases of success,the rate of partial placent and decidual fragments remain requirement uteus evacuation were lower in MMW group than in RII group ,The difference was significant(χ2=25.67>χ2 (0.005) P<0.005)the volume of hemorrhage within two hours of post partum was no significant difference in three group. The rate of labor within 24 hours and 48 hours was higher in MMW group than in RII group(χ2=47.11>>χ2 (0.05)=7.88 )P<0.05,and(χ2=7.264>? (0.01)=6.63) P<0.01.Compare with group MM,the total stage of labor was no significant difference(t=1.4674.05),and the rate of labor within 24hours in MMW group was higher than in MM group 63.3%,(χ2=8.464>χ2 (0.005)=7.88 )P<0.005。the rate of labor within 48 hours was higher in MMW group than in MM group also,but no significant difference in statistics.as far as beyond twenty weeks pragnacy age is concerned,the rate of labor within 48hours was higher in MMW group than in MM group the difference was significant.(χ2=4.886>χ2 (0.05)=3.84 P〈0.05).The dosage of misoprostol in MMW group were lower than in MM group. 381.25 micro and 783.37 micro respectively.The rate of applied misoprostol fewer than 600 microgram was 70% in MMW group and 50% in MM group respectively ,the difference was significant between two group. (χ2=6.484>χ2(0.05)=3.84 P<0.05)).nausea (30.5%) vomit (10%)and febrile (two case) were not serious after oral mifipristone and misoprostol needn't special treatment. no diarrhea occurred. Conclusion:the duration from induction...
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