Expression Of PTEN Protein In Breast Infiltrative Ductal Carcinoma And Its Relationship With Prognosis

Objective To study the expression and clinical significance of tumor suppressor gene PTEN in primary breast infiltrative ductal carcinoma.Methods Immunohistolchemical staining (S-P) was used to detect the expression of PTEN in 50 cases of primary breast infiltrative ductal carcinoma tissues.Results Among these 50 tissues, the rates of total expressing depletion of PTEN were 44%. Expression of PTEN was closely related to tumor size, histological grade and clinical stage. With the increasing of tumor size, histological grade and clinical stage, the rates of expressing depletion of PTEN raised , p<0.05. When the survival time were <60months, >0months and < 120 months, >20 months, the rates of expressing depletion of PTEN were 75.0%, 50.0%, and 8.4%, respectively. There were significant differences among the three groups , p<0.05. The rates of depletion of the PTEN expression of the two groups of tumor with or without axillary's lymph nodes metastases were 58.3% and 30. 8% respectively, p=0.05. But expression of PTEN was not different in ER positive group and ER negative group , p>0.05.Conclusion The depletion of the expression of PTEN at protein level may contribute to prognostic criterion for breast infiltrative ductal carcinoma.