The Sleeping-Respiration And Morphology Study Of Obstructive Sleep Apnea Syndrome

Obstructive Sleep Apnea Syndrome (OSAS)is a disease characterized by recurrent upper airway occlusion during sleep. The repetitive apneic episodes may result in sleep fragmentation and severe hypoxemia .Patients suffered from this disorder may develop a varity of complications,which include cardiovas- cular system, cerebrovascular system, respiratory system,urinary system et al.More and more researchers pay attention to the middle-aged who are in the high incidence of the OSAS. The results is different from each other because of the various of research methods and diagnostic criterions.In most epidemiology studies,question investigation is performed,those with evident symptoms (such as daytime sleepiness,sleep apnea )are selected to overnight polysmonography investigation.The estimated prevalence of OSAS,defined as an apnea-hypopnea score of 5 or 10.Many patients without evident symptoms are ignored .Some of these estimates are based on the extremely conservative assumption that all survey participants who did not report snoring and sleepiness were free of OSA,this assumption is almost certainly false and could lead to a serious underestimation of prevalence.There is little research on asymptomic adults ,Pay attention to the status of the sleep and respiration among these asymptomic general adults is needed. OSA is characterized by narrowing of the upper airway and a retrognathic mandible .There are various of anatomic risk factors for OSA because of various of research methods especially the choose of the control team. There is the difference in race between the East and West in the overseas articles.As a result it is essential to select and determine exact control team to evaluate craniofacial structure and determine where are the abnormals. The thesis includes the following studies: 1.Totally 30(20male,10female) asymptomatic general adults who were selected from 242 individuals were investigated by colligation questionnaire,Epworth Sleepiness Scale and Polysmonographic .The mean age of the sample was 43.81±4.67years old,boody mess index was 23.89±2.69Kg/m2.Prevalence of OSA based on a AHI of 5 is estimated to be 60%, AHI＞ 15 is 10% .It isn't optimistic for the sleep and respiratory stutas of the middle aged. Data suggests that the different diagnostic criterions should be used in different aged. 2.16 men(AHI 4.5±2.26) selected from study I as the control team compared with 31men(AHI38.66±17.89)with same age and same sex ratio,diagnosed as OSAS the same time.OSAS patients showed relative increased ANB, NA/PA, reduced dimesion of back gap of the soft palate and the nasopharynx size , enlarged tongue and caudally displaced hyoid.3.Bivariate correlation analysis was performed in 73 individuals between the craniofacial structures , upper airway and the respiratory disturbance .The results are as follows:⑴The variables of craniofacial structure correlated with respiratory disturbance were:mandibular body lengh,the angle between upper and lower central incisor.⑵The variables of upper airway correlated with respiratory disturbance were: back gap of the soft palate,the diameterof the nasopharynx,the sagittal position of hyoid.