| As one of the important organic compounds, phthalic acid esters (PAEs) are widely used in commercial productions. The potential for human exposure is high given their use in a vast range of products including pesticide carriers, medical packaging, cosmetics, insect repellents, emollients, children' toys, wood furniture, paints, and upholstery etc. Primarily, they were used widely as plasticizers in flexible polyvinyl chloride (PVC) plastics. The members of phthalic acid esters' family include di-n-butyl phthalate (DBP), butyl benzyl phthalate (BBP), di-n-methyl phthalate (DMP), di-n-ethyl phthalate (DEP), di-(2-ethylhexyl) phthalate (DEHP), di-n-octyl phthalate (DOP) etc. Some of them were called priority control pollutants by USEPA, and DBP was also called priority detection pollutant in China. Animal toxicological data of PAEs showed that DBP represented reproductive and developmental toxicity. It is estimated that total productions and consumptions of PAEs are 300-400 million tons per year in the world. The plasticizers are not irreversibly bound in the polymer matrix, by migrating from the plastic to the external environmental under certain use or disposal conditions, and would possibly bring about potential adverse effect on human health.All the 170 biosamples including 50 venous blood, 40 cord blood, 40 breast milk and 40 urine samples were collected from 50 healthy delivering women with the average age of 27.44±3.43 years old. Organic chemicals in these biosamples were determined qualitatively by gas chromatography/mass spectrometer (GC/MS) after extraction with hexane. DBP concentrations were determined quantitatively due to high detected-out frequency in these biosamples. Correlative relations were studied between DBP concentrations and birth length, weight, sex of newborns. In addition, the kinds of organic chemicals and DBP concentrations of commercial cow's milk productions in market were qualitatively analyzed and quantitatively determined by GC/MS respectively, and the results of it were compared with that of human milk. (1) Qualitative analysis of organic compounds in all biosamples from delivering women: The results were that 292 kinds of organic compounds were checked out, including 156 kinds in venous blood, 139 kinds in cord blood, 176 kinds in breast milk, 138 kinds in urine samples. The average kind of organic compounds which were checked out in each of venous blood, cord blood, breast milk, urine samples was 11.94±5.65, 9.58±3.99, 10.58±4.16 and 10.05±3.35, respectively. These data statistied by one-way ANOVA showed no significant difference among four groups. The sequence for kinds of organic chemicals were: venous blood > breast milk > urine samples >cord blood. The kinds of organic chemicals were the highest in venous blood owing to failing to be metabolized entile in human body. The less kinds of organic chemicals were in cord blood because some of them did not pass the placental barrier.9-Octadecenoic acid (82.00%), heptadecene-(8)-carbonic acid(66.00%), di-n-butyl phthalate ester(62.00%) were the most checked-out frequencies in venous blood. And 14-Bate-H-pregna(52.50%), di-n-butyl phthalate ester(37.50%), 9-octadecenoic acid (32.50%) were the most checked-out frequencies in the cord blood. In addition, 9-Octadecenoic acid (45.00%), thiosulfuric acid (H2S2O3)-S-(2-aminoethyl) ester(45.00%), Hahnfett(45.00%), di-n-butyl phthalate ester(30.00%) were the most checked-out frequencies in urine samples. Moreover, 9-Octadecenoic acid(52.94%), di-n-butyl phthalate ester (48.82%) were the most checked-out frequencies in four kinds of biosamples.Correlative analyses were performed between checked-out kinds of organic chemicals in four kinds of biosamples and ages of delivering women. However, all the correlation coefficients indicated no significant difference. It may be associated with distributed concentration of delivering women's ages.(2) Determined DBP concentrations in all biosamples from delivering women: According to the organic compounds qualitative analysis in 50...
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