Study Of Detecting Overexpression Of HER's Family In NSCLC And Their Clinical Content By IHC

Objective To detect the expression of human epidermal growth factof receptor (HER) family in non-small cell lung cancer (NSCLC) and investigating the relationship between their overexpression and the clinical pathology of lung cancer.Methods 58 cases of paraffin embedded tissues from lung cancer (32 cases of squamous cell cancer and 26 cases of adenocarcinoma) with 5 years of follow-up information were detected for the expression of HER family by means of Immunohistochemical assay.Results HER2,HER1,HER3,HER4 were over-expressed in lung cancer in 56.9%(33/58),63.8%(37/58),29.3%( 17/58)and 63.8%(37/58) respectively. There were co-expression between HER2 and other members of the HER family. HER2+1+3+4 were overexpressed in 19.0% ( 11/58 ) of the cases. The over-expression of HER2, HER1, HER3, HER4, HER2+1+3+4 in lung cancer correlated with lymph node metastasis, TNM staging and five year survival after operation.Conclusion The genes of HER2, HER1, HER3 and HER4 regulate tie growth of lung cancer at advanced stages and HERs' overexpression mightbe an important prognostic indicator of the survival of lung caner alter operation. Detection of HERs1 over-expression as a routine can provide a new important approach to evaluate the treatment of lung cancer.