Experimental Research On The Effect Of XieXinTang On Myocardial Ischemia, Hypercholesterolemia And Its Mechanism

Objection: to explore XieXinTang (XXT)' s functional mechanism an myocardial ischemia ,Methods: This study used Pituitrin to induce myocardial ischemia in the rais and fed the rats with high cholesterol food to induce hypercholesteraemia ,and observed the eifects of XXT on the ECG ,CK ,CK-MB ,TC, LDL-C ,HDL-C in animal models ,and compared them with the group of XiaoXinTong Tablet (XXTT), the group of modle and the normal group simultaneously.Result: XXT could resist the change of ST 2 in myocardial ischemia in rats ,which was particularly obvious in middle and the high dosage group (P < 0.05).It could decrease the levels of CK, CK-MB in myocardial ischemia in the rats . The middle and the high dosage group were especially effective in these indexes (P < 0.05).And the differences between XXT aftd XXTT had no statistical significance (P > 0.05).XXT could decrease the levels of TC,LDL-C and increase the levels of HDL-C in hypercholesteraemia The middte and the hige dosage group were especially effective in these indexes (P<0.05).Conclusion: XXT was effective in improving the change of ST segament of ECG during myocardial ischemia ,reducing the levels of CK, CK-MB in blood and alleviating the myocardial injury ,and reducing the levels of TC, LDL-C increasing the levels of HDL-C .The research indicate that XXT has an antagonistic effect on the experimental myocardial ischemia and hypercholesteraemia, which is worthy of going into further studying.