Evaluation Of Biological Safety Of Carbon-fibre Reinforced Resin Compound

The use of carbon is widespread in fields as wide as aeronautics, cars, electricity or electronics. The biomedical applications of carbon are also numerous. Metals, plastic, and ceramics have all been used for making implants. Of the metals titanium and some titanium alloys have proved particularly suitable. The plastics and ceramics have poor physical properties for dental implant construction on their own, although composites, many of which are biocompatible, such as hydroxyapatite reinforced polyethylene and carbon fibre reinforced carbon may overcome these problems. Compared to metal alloys (such as titanium and titanium alloys), conventional, large dimension, carbon fibers utilized for orthopedic implants have long been appreciated for their anisotropic mechanical properties~[1-11]; these material formulations, however, do not represent the ideal biomaterial due to results of clinical studies often demonstrating insufficient bonding to juxtaposed tissue leading to clinical failure~[9].So it is necessary to invest a high bioactive material .This article aims at evaluation of the biological safety of carbon fibre reinforced resin investigated by Zhejiang University and westlake biological materials limited company. .Objective: To evaluate the biological safety of carbon-fibre reinforced composite as a dental material.Methods: Three tests were chosen in this study, namely short-term systemic toxicity (oral route), acute systemic toxicity test(introvenous route)and haemolysis test.Result: Test 1. None of the rats was abnormal, there was no significant differences inutility rate of forage and relative rising rate of weight between the experimental group and control group(p>0.05). The internal organs had no pathological change. Test 2. All mice had no toxic sign, there was no significant difference in the change of weight between the experiment group and control group(p>0.05).No pathological change was found in the internal organs. Test 3.Acute haemolysis rate in vitro of the material was 2%.Conclusion: Carbon-fibre reinforced resin compound had no acute systemic toxic action on animals and haemolysis effect in vitro.