Comparative Study Of ～(18)F-FDG-PET, CT-Scan And Serum Tumor Markers Test In Diagnosis Of Lung Cancer

Objective: To search a scientific project for clinic to diagnose lung cancer by comparing the sensibility, specificity and accuracy of ¹⁸F-FDG-PET, thoracic CT-scan and serum tumor markers test in diagnosing lung cancer.Method: From June 2004 to January 2005, 63 patients with indeterminate pulmonary lesions were enrolled in this study prospectively. They all received CT-scan, ¹⁸F-FDG-PET and Serum Tumor Markers (CEA, Cyfra21.1, ProGRP) test before the surgery were operated. They were compared with pathological results, and then we calculated the sensibility, specificity and accuracy of each method.Results: Compared with pathological diagnosis results, the sensitivity of ¹⁸F-FDG-PET, thoracic CT-scan and serum tumor markers were 90.9% (40/44), 88.6% (39/44), 59.1% (26/44) respectively; the specificity were 57.9% (11/19), 36.8% (7/19), 94.7% (18/19) respectively; the accuracy were 81.0% (51/63), 73.0% (46/63), 69.8% (44/63) respectively. The diagnosis sensitivity of CT-scan and serum tumor markers was lower than ¹⁸F-FDG-PET (P ≤ 0.05) significantly; the diagnosis specificity of ¹⁸F-FDG-PET and thoracic CT was significantly lower than serum tumor markers (P ≤ 0.05). The accuracy of them had no significant deviation (P>0.05). In the combined styles, ¹⁸F-FDG-PET together with CT-scan and serum tumor markers had a 100 percent sensitivity and specificity (P ≤ 0.05). ¹⁸F-FDG-PET together with serum tumor markers had a 100 percent specificity and a 95.8 percent sensitivity. The accuracy of all the combined styles had no significant deviation...