Influential Factors Of Diseased Region And Degree Of Left Anterior Descending Branch Of Coronary Artery And The Analysis Of Correlation

ObjectiveCoronary artery atherosclerosis ( CAS) is the basic pathological change of coronary artery atheroclerosis heart disease ( CHD) , The theory of hazardous factors is a new strategy of prevention and therapy of CHD. hypertension , hyperlipemia , diabetes, and smokingare the major hazardous factors recognized, in addition , low high density lipoprotein cholesterol ( HDL - C) , non - high density lipoprotein cholestero (NHDL - C) , total - cholestero ( TC ) /HDL - C, low - density lipoproteincholesterol( LDL - C )/HDL - C,serum total bilirubin(TBIL) ,fibrinogen ( FIB ) and high coagulation situation and so on are recognized the isolated hazardous factors and main prediction index of CHD. Particularly, TC/HDL - C ,TG/HDL - C, LDL - C/HDL - C. but now there are different conclusions for TG, HDL - C in the country. Cause is being increasingly studied. At present, pulse pressure (PP) is more important than that of systolic pressure (SBP) and diastolic pressure ( DBP). Electrocardiogram ( ECG) is the most easy test. The pathology change of LAD is the highest. Now there isnt the study for the different site stricture degree of LAD and the numric effected indexes of ECG. The main study of the thesis are these factors of age, sex, hypertension, diabetes smoking, drinking, pulse pressure, blood type, blood - lipid, serumtotal bilirubin, coagulation situation and fibrinogenfor the effection of different site and stricture degree, which the numric effection of heart rate, QRS - period, PR - period, QT - period, QTC -time.Experiment Materials And MethodsStudy ObjectivesAll patients studied, who thoralic constriction, discomfort and acute coronary syndromes have examed with coronary angiography ( CAG) instrument in the first affiliated hospital of China Medical University during Jan. 1997 to Apr. 2004. According to the result of coronary angiography. All patients are divided into these groups, the normal group 26 patients (A Group) ,the beginning section of LAD group 89 patients (B group) , the middle and distant section of LAD group84 patients ( C Group). According to the stricture degree in the beginning section of LAD group, 18 payients are less 50 % (Bt) ,17 patients are 1n 50% - 74% ( B2 ) , 19 patients are 75% - 94% ( B3 ) , 17 patients are 95% - 99% (B4) ,19 patients are 100% (B5). In the middle and distant section group 19 patients (C1) ,15 patients (C2) ,17 patients (C3) ,17 patients (c4) ,16 patients (C5).Choose standard:The result of CAG should be the main pathology of LAD , the pathology of else branches are less 50% and arent the related vessel,no stricture in the left main coronary artery . smoker is more than 10 in one day,drinking is morn than 30 gram in one day, hypertension SBp ≥ 140mmHg, DBP ≥ 90mmHg, FPG ≥ 7. 0mmoL/l,2h PG ≥ 11. 1 mmoL/LDeleting standard; Liver disease, nephritic syndromes, hypothyroidism severe ionfection.Studying Methods:This study is review and xontrol trial, 199 patients with CAG,according to the result of CAG were divided into different group。 Including, the normal group 26 patients ( A) , LAD beginning section group 89 patients (B), LADF middle and distantsectiongroup 84 patiengs (C). Accoring to the stricture degree, these patients are divided intothese groups, including less 50% ,50% -74% ,75% -94% ,95% - 99% , 100%. Evaluating the correlation of hazardous factors and the different site or stricture degree.Statistical analysis;Quantitation data are expressed as mean sd, t - test and analysis of vari-ance. numric data adopt chi — square test and the analysis of correlationand regression , establish logistic regressive model. All data are analogized with the Spssl2. Osoft system,p <0. 05 has the significance.ResultsThere is the regressive relation among age, sex, hypertension, blood type, smoking, drinking and the stricture degree of LAD. There is more closely positive correlation, there is correlation among heart rate , QRS - period, QTC - time and stricture degree. Partial thromboplastin time and site are correlative, there isn t correlation between site and the indexes of ECG, age has significance between normal group and pathology group, value of the pulse pressure in the normal group is 42. 31 11. 94mmHg, there is significant in the distribution of blood type. Smoking and diabetes have significance in pathology group. That age, sex, hypertention, diabetes, pulse - pressure, blood - type, smoking and drinking hasn 's significance in different site, sex, hypertention, drinking havent significance a-mong the different stricture degree, value of HDL - C is 1. 07 0. 20mmol/l in the normal group. With the stricture degree, the value reduce to 0.94 0. 24mmol/l. value of the LDL - C/HDL - C is 2. 78 0. 65, the value of TC/HDL - C is 4.56 0. 75, value of prothrombin time has significance among the stricture group. The value APTT is 31.42 4. 41 second, value of FIB is increasing with the stricture degree,which is 3. 85 1.21g/L in the 100% stricture group. There isnt correlation and significance among site degree and serum total bilirubin. The time of QTC is 409.08 30. 85ms. There isnt significance between the stricture site and the indexes of ECG.DiscussionThe hazardous factors is a hypothesis of atherosclerosis. At present , many perspective cohort studies have confirmthat thereis relation among hypertension , hyperlipemia, diabetes, smoking and CHD. The result of study have indicated that there is correlation among age, sex, hypertension, blood type, smoking,...