| Objectives:Tinnitus is commonly and frequently encountered in otorhinolaryngology, it is also the puzzled medical problem in the world. Though there are many therapy methods on Clinic, there are still no conclusive methods. So it is a kind of difficult problem which is needed to solve urgently. TCM therapy has superiority in prevention and cure tinnitus. Therapy methods based on syndrome differentiation is the essence methods of TCM. Syndrome differentiation is precondition of therapy, if syndrome differentiation is correct, there is good curative effect. In traditional methods of syndrome differentiation the information is collected by four diagnostic methods,and analyzed synthetically, then a kind of syndrome which reflects the essence of the disease is found . But on clinic, we also found that many patients of tinnitus did not accompany with other discomfort or symptom, wich made it, difficult for syndrome differentiation by four diagnostic methods in TCM. Recently many medicines find that "field of vision" is widend rescur to modern medical measures , veracity of syndrome differentiation is increased in a way, which make syndrome differentiation to be more object and compellent. In the research of objective and normalization of TCM syndrome , otologist had found that audiology test may be conducive to the differentiation of symptoms, the study proceed from simple index to more indexes, and combined the statistical method of multivariate discriminant analysis, they studied common symptoms of wind-heat invading, liver-fire, depression of phlegm-fire, kidney deficiency, and weakness of spleen of tinnitus, and summarize discriminant function based on audiology index, and compare them with personal syndromes. The study aimed to verify the 5 syndrome-functions on clinic, offer clinical data to adjust and consummate the functions.Methods:All patient selected according to criterion of tinnitus corned from the first hospital of Guangzhou TCM university from 2004, Feb. to 2005, Jan.And syndrome differentiation was made by two doctors whose professional title were associate professor at least according to traditional 4 diagnostic methods. The syndrome is regarded as gold criterion. Pure tone test, acoustic immittance measurement and auditory brainstem response about 17 audiology indexes were detected for each patient. ALL datas were added into multielement discriminant function ,and computed to an objective type of syndrome. Sensitivity, specificity and accuracy of each symdrome was calculated. Double blind method was used to control bias in the study.Results:52 tinnitus patients with typical syndrome of TCM were detected in the prospective trial. There are 10 wind-heat invading, 6 liver-fire, 7 depression of phlegm-fire, 13 weakness of spleen and 16 kidney deficiency. The results of objective rescrub of audiology index are as follows: Wind-heat invading was most accurate in verification, had a sensitivity of 80% and specificity of 85. 7%, accuracy of 84.6%. It' s rate of misjudgement is lowest, it is 20%, 2 patients are misjudgemented, and 1 patient of wind-heat invading is misjudgemented to one of depression of phlegm-fire, and another is misjudgemented to weakness of spleen. Kidney deficiency had lowest accurate rate, with sensitivity of 18.8%, specificity of 97. 2%, and accuracy of 73. 1%, and had the highest rate of misjudgement which is 81.2%. 13 patients are misjudgemented, 5 tinnitus of kidney deficiency are misjudgemented to those of wind-heat invading, and 6 tinnitus of kidney deficiency are misjudgemented to those of liver-fire, and 2 patients are misjudgemented to those of depression of phlegm-fire. Liver-fire had a sensitivity of 66. 7%, specificity of 78. 3%, and accuracy of 76.9%. and had a rate of misjudgement of 33. 3%. 2 patients of liver-fire were misjudgementer to those of depression of phlegm-fire. Depression of phlegm-fire had a sensitivity of 42.9%, specificity of 84.4%, and accuracy of 78.9%, and had a rate of misjudgement of 57.1 % . 4 patients are misjudgemented, 1 patient of depression of phlegm-fire was misjudgemented to one of wind-heat invading, 1 was liver-fire, and 1 was weakness of spleen. There was 1 patient of depression of phlegm-fire which can not be classified to any syndrome. Weakness of spleen was of sensitivity at 53.8%, specificity at 98. 9%, and accuracy at 79. 6%, and had a rate of misjudgement of 46. 2%. 6 patients are misjudgemented, 3 patients of weakness of spleen were misjudgemented to those of liver-fire,2. patients of weakness of spleen were misjudgemented to those of depression of...
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