Expression Of MMP2 And Ki67 In Endometrial Hyperplasia And Endometrial Adennocarcinoma

Object To study the significance of MMP2 and ki67 Expression in endometrial hyperplasia and endometrial adennocarcinomaMethods The expression of MMP2 and ki67 proteins was detected by immumohistochemical staining S-P method in cases of endometrial hyperplasia and cases of endometrial adennocarcinomaResults In endometrial proliferation , simple hyperplasia. complex hyperplasia. atypical hyperplasia and endometrial adennocarcinomaN the positive expression rates of MMP2 werelO %(2/20) . 13.3%(4/30) . 33.3%(10/30) . 70%(21/30) . 82.5%(66/80). ;while those of ki67 were 20% (4/20). 26.7% (8/30 ). 46.7% (14/30). 63.3% (19/30 ). 75% (60/80 ). The expression rates of endometrial adennocarcinoma were all significantly higher than those in endometrial proliferation . simple hyperplasia. complex hyperplasia (P<0.01). There was no difference in expression rates of MMP2 and ki67 in atypical hyperplasia and endometrial adennocarcinoma(P>0.05). (2) The expression rates of MMP2 and ki67 in adennocarcinoma with histoiogical G2 were 50 %(12/24). 41.7 %(10/24) , . those in adennocarcinoma with histoiogical G3 were 42.9 %(6/14). 28.6 %(4/14). The expression rates in adennocarcinoma with histoiogical G2 and G3 were all higher than those in adennocarcinoma with histoiogical G1. (P<0.05). (3) The expression rates of MMP2 in group invading musculars were higher than those in group no- invading musculars (P<0.05).There was no difference in expression rates of KI67 in group invading musculars and in group no- invading musculars (P>0.05). (4) The expression rates of MMP2 in group with lymph metastasis node was 100%(4/4); .those in group without lymph metastasis node was 27.6%(21/76) .The expression rates of MMP2 in group with lymph metastasis node was higher than those in group without lymph metastasis node (P<0.05). The expression rates of KI67 in group with lymph metastasis node was 50%(2/4); .those in group without lymph metastasis node was 23.7%(18/76). There was no difference in expression rates of KI67 in group with lymph metastasis and in...