The Change And Clinical Significance Of Serum Vascular Endothelial Growth Factor With Congestive Heart Failure

Objective: Serum VEGF and CRP in patients with Congestive Heart Failure (CHF) were measured in order to investigate the change of VEGF in patients with CHF, the relationship between VEGF and the severity of symptoms in patients with chronic CHF , and the correlation between VEGF and CRP . Disccussed how the comorbid disease (including Diabetes (DM), Hypercholesteremia (HC), Hypertention and stable angina pactoris) influence the expression of VEGF in patients with CHF.Methods: This study was carried out in 100 patients admitted to hospital with the primary diagnosis of CHF. Of these, 31 patients were acute CHF (group IV), 32 were chronic CHF with NYHA function class III or IV (group III), 37 were chronic CHF with NYHA function class II (group II). 35 healthy hospital staffs were recruited as normal controls (group I). Venous blood work was performed in the first morning after hospital admission. Each patient was measured the serum levels of VEGF and CRP. Compared the VEGF and CRP levels among those study groups. Analyzed the correlation of VEGF and CRP according to the comorbid diseases.Results: 1. Comparing with the normal controls (77.34±16.29 pg/ml ), the serum levels of VEGF were significantly higher in acute CHF group (151. 48±30. 07 pg/ml , p<0. 05), mild chronic CHF group (109. 84± 26. 28pg/ml , P<0. 05), and sever chronic CHF group (109. 84 ± 26. 28pg/ml, p<0. 05). Acute CHF group has significantly higher VEGF level than chronic CHF groups ( p<0.05). There was no significant difference between mild chronic CHF ( group II, p>0.05) and sever chronic CHF ( group III , p>0. 05) regarding of the VEGF level. 2. CRP was significantly higher in acute CHF group (16.83± 12.06 mg/1) , p<0. 05) , group 11(17. 79± 12. 80 mg/1 , P<0. 05) and group III (17.79±12.80 mg/1, p<0. 05) than the normal control (3.99 ± 1. 89 mg/1). 3. The data showed certain association between VEGF and CRP, but was not significant. (r=0.1786; P>0.05). 4. Non of the comorbid diseases (Diabets, Hypercholesteremia, Hypertention , stable angina pectoris) contributed...