Correlation Between Tumor-associated Macrophages And MMP-2, Ki67 In Colorectal Carcinoma

Objective:The aim of this study was to detect tumor associated macrophages(TAMs) count、the expression of Matrix metalloproteinase-2(MMP-2) and cell proliferation marker(Ki67) in colorectal carcinoma, so as to explore TAMs s influence on the invasion,metastasis, proliferation and prognosis of colorectal cancer. Methods:55 cases of colorectal cancer in Qingdao Municipal Hospital from 2012 to 2013 and 55 cases of corresponding normal colonic tissue (5cm away from the cancer) were collected to detect TAMs count, MMP-2 and Ki-67 expression with immunohistochemistry SP. Results:1. TAMs counts MMP-2 and Ki-67 expression in colorectal cancer are significantly higher than those in normal colonic tissue(P<0.05).2. With lower degree of differentiation, increase numbers of lymph node metastasis and deeper of infiltration, the result of TAMs counts MMP-2 and Ki-67 expression was significantly increase (P<0.05).3. TAMs count is positively correlated with the expression of MMP-2(r=0.625 P=0)、 Ki-67(r=0.690 P=0) in colorectal carcinoma.4. The patients with low expression of TAMs, MMP-2 and Ki-67 live remarkably longer than those with high expression (P<0.05). Conclusion:1. TAMs count、 MMP-2 and Ki-67 expression in colorectal cancer can be used as an indicator to judge the prognosis of colorectal cancer.2. TAMs may promote tumor invasion、metastasis、proliferation and affect patients’ prognosis by secreting MMP-2 and other cytokines.